循环肿瘤细胞对胰腺癌诊断价值的Meta分析

发布时间：2018-05-07 07:13

本文选题：胰腺肿瘤 + 肿瘤细胞　；参考：《中国普通外科杂志》2017年03期

【摘要】：目的:通过Meta分析系统评价外周循环肿瘤细胞(CTCs)在胰腺癌患者中的诊断中的价值。方法:计算机检索多个国内外数据库,收集已发表关于CTCs在胰腺癌患者与非胰腺癌人群中检测的研究,检索起止时间均为建库至2016年8月31日。按照纳入标准筛选文献、提取资料和质量评价后,采用Metadisc1.4和Stata12.0软件对纳入研究进行Meta分析。结果:共纳入19篇文献,包含693例胰腺癌患者和406例非胰腺癌对照。采用随机效应模型进行统计量,得到CTCs检测对胰腺癌检出的合并敏感性为0.67(95%CI=0.63~0.60),合并特异性为0.94(95%CI=0.91~0.96),合并诊断优势比DOR为50.47(95%CI=20.13~126.55),合并诊断阳性似然比和阴性似然比分别为11.15(95%CI=5.42~22.95)、0.36(95%CI=0.28~0.45);总受试者工作特征曲线下面积为0.93,Q*值为0.03,诊断性试验Deek漏斗图显示存在发表偏倚。结论:目前CTCs尚不足以单独作为胰腺癌早期诊断指标,但可作为胰腺癌诊断方法的重要补充。
[Abstract]:Objective: to evaluate the diagnostic value of peripheral circulating tumor cells (CTCs) in patients with pancreatic cancer by Meta analysis system. Methods: a number of databases at home and abroad were searched, and published studies on the detection of CTCs in pancreatic cancer patients and non-pancreatic cancer patients were collected. The data were extracted and evaluated according to the inclusion criteria. Meta analysis was carried out by using Metadisc1.4 and Stata12.0 software. Results: a total of 19 articles were included, including 693 pancreatic cancer patients and 406 non-pancreatic cancer controls. The random effect model is used to carry out the statistics. The combined sensitivity of CTCs to the detection of pancreatic cancer is 0.67 ~ 95CII 0.63 / 0.60, the combined specificity is 0.94 / 95CI0.91 / 0.96, and the odds of combining diagnosis is 50.4795 / 95 ~ 20.13126.55 / DOR, respectively. The positive likelihood ratio and negative likelihood ratio of the combined diagnosis are 11.1595CI5.42 ~ 22.995 / 0.3695 / 0.3695 ~ (0.45), respectively; the area under the total operating characteristic curve of the subjects is 0.93Q* * The Deek funnel diagram of diagnostic test showed publication bias. Conclusion: at present, CTCs can not be used as an early diagnostic marker of pancreatic cancer alone, but it can be used as an important supplement for the diagnosis of pancreatic cancer.
【作者单位】：泰山医学院研究生院;浙江省嘉兴市第二医院肝胆外科;
【基金】：浙江省嘉兴市社会发展计划基金资助项目(2016AY23057)
【分类号】：R735.9

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