PVT1在恶性肿瘤发生发展中的作用及机制

发布时间：2018-05-09 11:25

本文选题：恶性肿瘤 + 长链非编码RNA　；参考：《生物化学与生物物理进展》2017年11期

【摘要】：长链非编码RNA在调节细胞的生长、分化及其他生物学过程中具有重要作用,且与恶性肿瘤等常见疾病密切相关.人类长链非编码RNA PVT1的编码基因由于位于染色体8q24这一脆性位点且临近癌基因MYC而受到广泛关注.浆细胞瘤可变异位基因1(PVT1)在多种肿瘤中高表达,是潜在的癌基因;PVT1也能因染色体断裂重排而与其他基因形成新的融合基因影响恶性肿瘤的表型;PVT1还可与MYC基因相互作用,通过多种途径参与恶性肿瘤细胞的增殖、凋亡等调控.本文对PVT1在恶性肿瘤发生发展中的作用及其机制进行综述.
[Abstract]:Long chain noncoding RNA plays an important role in regulating cell growth, differentiation and other biological processes, and is closely related to common diseases such as malignant tumors. The encoding genes of human long chain non-coding RNA PVT1 are widely concerned because they are located at the fragile site of chromosome 8q24 and are adjacent to the oncogene MYC. Plasmacytoma variable heterotopic gene 1 (PVT1) is highly expressed in many kinds of tumors, and it is a potential oncogene, PVT1 can also form a new fusion gene with other genes because of chromosome break rearrangement to influence the phenotype of malignant tumor. PVT1 can also interact with MYC gene. It participates in the regulation of proliferation and apoptosis of malignant tumor cells through many ways. This article reviews the role and mechanism of PVT1 in the development of malignant tumors.
【作者单位】：中南大学湘雅医学院附属肿瘤医院湖南省肿瘤医院;中南大学肿瘤研究所卫生部癌变原理重点实验室;中南大学湘雅医院教育部癌变与侵袭原理重点实验室;中南大学湘雅二医院;中南大学湘雅三医院湖南省非可控性炎症与肿瘤重点实验室;
【基金】：国家自然科学基金(81372907,81472531,81572787,81672683,81672993) 湖南省自然科学基金(2015JJ1022)资助项目~~
【分类号】：R730.231

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