保妇康栓联合壳聚糖抗菌膜对宫颈上皮内瘤变患者行宫颈锥切术后疗效及相关指标的影响

发布时间：2018-05-09 12:46

本文选题：保妇康栓 + 壳聚糖抗菌膜　；参考：《中国药房》2017年03期

【摘要】：目的:探讨保妇康栓联合壳聚糖抗菌膜对宫颈上皮内瘤变(CIN)患者行宫颈锥切术后疗效及相关指标的影响。方法:200例拟行宫颈锥切术的CIN患者随机分为对照组(100例)和观察组(100例)。两组患者均于月经干净2~7 d后行宫颈锥切术;术后,对照组患者给予壳聚糖抗菌膜1片,以无菌操作杆推入阴道并贴敷于创面,以纱块进行填塞,每2 d更换1次;观察组患者在对照组治疗的基础上给予保妇康栓1粒,阴道置入,每日1次。两组疗程均为2周。观察两组患者的临床疗效,创面愈合时间、阴道排液时间,治疗前后的炎症因子[白细胞介素(IL)-4、IL-10、肿瘤坏死因子(TNF)-α]水平,记录术后并发症及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,创面愈合时间和阴道排液时间均显著短于对照组,术后并发症发生率显著低于对照组,差异均有统计学意义(P0.05)。治疗后,两组患者炎症因子水平均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:宫颈锥切术后,保妇康栓联合壳聚糖抗菌膜治疗CIN的疗效显著,可有效提高术后患者创面愈合效果,降低炎症反应水平及术后并发症发生率,且不增加不良反应的发生。
[Abstract]:Objective: to investigate the effect of Baofukang suppository combined with chitosan antibacterial membrane on the postoperative efficacy and related indexes of cervical intraepithelial neoplasia (CINs) patients. Methods two hundred patients with CIN were randomly divided into control group (n = 100) and observation group (n = 100). The patients in both groups were treated with cervical conization 7 days after menorrhagia, the patients in control group were treated with chitosan antibacterial film 1 tablet, and then applied to the wound with aseptic pole, then filled with yarn and replaced once every 2 days. The patients in the observation group were given 1 capsule of Baofukang suppository on the basis of treatment in the control group, and the vagina was implanted once a day. The course of treatment was 2 weeks in both groups. The clinical efficacy, wound healing time, vaginal effusion time, the levels of inflammatory factor IL-10 and tumor necrosis factor TNF- 伪 before and after treatment were observed in the two groups. The postoperative complications and adverse reactions were recorded. Results: the total effective rate in the observation group was significantly higher than that in the control group, the wound healing time and vaginal drainage time were significantly shorter than those in the control group, and the incidence of postoperative complications was significantly lower than that in the control group (P 0.05). After treatment, the levels of inflammatory factors in both groups were significantly lower than those before treatment in the same group, and the levels of inflammatory factors in the observation group were significantly lower than those in the control group (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: Baofukang suppository combined with chitosan antimicrobial membrane is effective in the treatment of CIN, which can effectively improve the wound healing effect, reduce the level of inflammatory reaction and the incidence of postoperative complications, and do not increase the incidence of adverse reactions.
【作者单位】：漯河市中心医院;漯河医学高等专科学校药学系;漯河市第三人民医院药剂科;
【分类号】：R737.33

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