血清CA125、HE4和哥本哈根指数在卵巢上皮性肿瘤良恶性鉴别诊断中的价值

发布时间：2018-05-09 15:00

本文选题：卵巢上皮性肿瘤 + CA　；参考：《南方医科大学学报》2017年05期

【摘要】：目的探讨基于治疗前血清CA125、HE4水平和年龄的哥本哈根指数在鉴别卵巢上皮性肿瘤良恶性中的应用价值。方法回顾性分析2014年9月~2016年9月就诊于南方医科大学南方医院妇产科的208例卵巢上皮性肿瘤连续病例(良性108例+恶性100例),以手术病理诊断结果为金标准绘制ROC曲线,得出灵敏度和特异度,比较CA125、HE4、哥本哈根指数鉴别卵巢上皮性肿瘤良恶性的效能。结果在总体人群、早期病例、晚期病例中,卵巢癌组CA125、HE4、哥本哈根指数预测值均高于良性肿瘤组,差异有统计学意义(P0.001);CA125、HE4、哥本哈根指数鉴别卵巢上皮性肿瘤良恶性的灵敏度依次是81.0%、86.0%、91.0%(总体人群),64.0%、68.0%、72.0%(早期病例),86.7%、92.0%、97.3%(晚期病例),特异度依次是88.0%、93.5%、96.3%。其中哥本哈根指数灵敏度、特异度均最高,HE4次之,CA125最低,两两相比,除在早期人群中的灵敏度外,余差异均有统计学意义(P0.001)。结论基于患者血清CA125、HE4值及年龄的哥本哈根指数较单独应用HE4或CA125具有更为良好的诊断效能,可用于卵巢上皮性肿瘤良恶性的鉴别诊断,提高卵巢癌早期诊断率。
[Abstract]:Objective to evaluate the value of the Copenhagen index based on serum CA125 he4 level and age in differentiating benign and malignant ovarian epithelial tumors. Methods from September 2014 to September 2016, 208 consecutive cases of ovarian epithelial neoplasms (108 benign and 100 malignant) in the Department of Obstetrics and Gynecology, Southern Hospital of Southern Medical University, were retrospectively analyzed. The ROC curve was drawn according to the gold standard of surgical and pathological diagnosis. Sensitivity and specificity were obtained to compare the effectiveness of CA 125 he 4 and Copenhagen index in differentiating benign and malignant ovarian epithelial tumors. Results the predicted values of CA125HE4, Copenhagen index in ovarian cancer group were higher than those in benign tumor group in general population, early cases and advanced cases. The sensitivity of Copenhagen index in differentiating benign and malignant ovarian epithelial tumors was 81.0, 86.0 and 91.0, respectively. The sensitivity and specificity of Copenhagen index were the highest and CA125 was the lowest, except for the sensitivity in early population, the difference was statistically significant (P 0.001). Conclusion the Copenhagen index based on serum CA125 HE4 and age is more effective than HE4 or CA125 alone in the diagnosis of ovarian epithelial neoplasms, which can be used to differentiate benign and malignant ovarian tumors and improve the rate of early diagnosis of ovarian cancer.
【作者单位】：南方医科大学南方医院妇产科;南方医科大学南方医院PET中心;重庆医科大学附属第二医院妇产科;
【基金】：广东省科技计划(2016A020215115) 花都区科技计划(HD15CXY006) 天河区科技计划(201604KW010)
【分类号】：R737.31

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