肿瘤因子α-L-岩藻糖苷酶参考值的空间分布规律

发布时间：2018-05-11 18:28

本文选题：α-L-岩藻糖苷酶 + 地理因素　；参考：《中山大学学报(医学科学版)》2017年03期

【摘要】：【目的】研究中国健康成年人α-L-岩藻糖苷酶(AFU)空间分布趋势及其与地理因素之间的关系,为临床制定AFU科学标准提供地域性依据。【方法】收集2004-2015年全国66个市县级单位测定的6 564例健康人AFU参考值,其中男性3 701例(56.4%)女性2 863例(46.3%),运用信息含量法从22项地理因素中筛选出11项因素,并采用岭回归分析模拟出全国2322个市县级单位的参考值,然后运用地统计分析方法,分析AFU参考值在空间位置的分布特征。【结果】我国2 322个市县级单位健康成年人AFU参考值在空间上存在自相关特征,空间分布上呈现出东部高、西部低、北部高、南部低的空间分布趋势。【结论】AFU参考值在空间上存在变异性,因此在临床诊断中应该考虑地域性差异。
[Abstract]:[Objective] to study the spatial distribution trend of alpha -L- fucosidase (AFU) and its relationship with geographical factors in Chinese healthy adults, and to provide regional basis for the clinical formulation of AFU scientific standards. [Methods] 6564 healthy people from 66 City county-level units were collected for 2004-2015 years, of which 3701 (56.4%) women were male. 2863 cases (46.3%), using the information content method to select 11 factors from 22 geographical factors, and use the ridge regression analysis to simulate the reference value of the country's 2322 City county-level units, and then use the land statistical analysis method to analyze the distribution characteristics of the AFU reference value in the space position. [results] 2322 City county-level units in China are healthy adults AFU. The reference values have autocorrelation features in space, and the spatial distribution shows the trend of spatial distribution of High East, low West, high north and low south. [Conclusion] AFU reference value exists variability in space, so regional differences should be considered in clinical diagnosis.

【作者单位】：陕西师范大学旅游与环境学院健康地理研究所;地理学国家级实验教学示范中心(陕西师范大学);西安交通大学医学院第二附属医院心内科;
【基金】：国家自然科学基金(40971060) 陕西师范大学研究生创新基金重点项目(2016CSZ005) 中央高校基金资助项目(GK201504015)
【分类号】：R735.7

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