雄激素受体对三阴性乳腺癌患者生存状况影响的Meta分析

发布时间：2018-05-15 01:42

本文选题：三阴性乳腺癌 + 雄激素受体　；参考：《吉林大学学报(医学版)》2017年01期

【摘要】：目的:系统评价雄激素受体(AR)对三阴性乳腺癌患者生存状况的影响,探讨AR阳性和阴性乳腺癌患者生存率的差异。方法:计算机检索PubMed、Medline、EMbase、Cochrane Library、中国生物医学文献服务系统(CBM)、相关期刊论文(CNKI)、万方数据库和维普数据库中关于AR对三阴性乳腺癌患者生存状况影响的相关研究,采用RevMan 5.1软件进行Meta分析。结果:最终纳入文献9篇,其中英文文献5篇,中文文献4篇,均为队列研究。研究对象1 295例,其中AR阴性患者933例,阳性患者362例。文献质量评价,7篇文献得分7分,2篇文献7分。合并效应量结果,三阴性乳腺癌AR阳性和阴性患者无病生存率(DFS)和总生存率(OS)比较差异无统计学意义(OR=0.70,95%CI:0.33~1.46,P=0.32;OR=0.41,95%CI:0.17~0.98,P=0.05),AR阳性患者5年DFS和OS明显高于AR阴性患者(OR=0.30,95%CI:0.11~0.86,P=0.02;OR=0.19,95%CI:0.11~0.33,P0.01)。结论:AR对三阴性乳腺癌患者5年DFS和OS存在积极影响,但尚不能证实其对三阴性乳腺癌患者3年或10年生存率的影响作用。
[Abstract]:Objective: to evaluate the effect of androgen receptor (AR) on survival status of triple negative breast cancer patients and to explore the difference of survival rate between AR positive and negative breast cancer patients. Methods: a computer-based search of PubMedline Medline for Cochrane Library, China Biomedical document Service system (CBMN), China Journal Full-text Database (CNKI), Wanfang Database and Weip Database were conducted to investigate the effects of AR on the survival status of triple-negative breast cancer patients. Meta analysis was carried out with RevMan 5.1 software. Results: 9 papers were included, including 5 in Chinese and 5 in Chinese, all of which were cohort studies. The study included 1 295 patients, of whom 933 were AR negative and 362 were positive. The evaluation of literature quality included 7 points of 7 articles and 7 points of 2 articles. There was no significant difference between the disease-free survival rate (DFS) and the overall survival rate (OS) in patients with AR positive and negative breast cancer. There was no significant difference between the two groups. There was no significant difference in DFS and OS between 0.7095 CI: 0.331.46P0.32P0.32P0.41 / 95CI: 0.1780.908P0.05AR positive patients with DFS and OS in 5 years were significantly higher than those in AR-negative patients (0.30g / 95CI: 0.110.86P0.02ORP = 0.1995CI: 0.110.333P 0.01). Conclusion: the effect of + AR on 5-year DFS and OS in patients with triple-negative breast cancer is positive, but its effect on 3-year or 10-year survival rate of tri-negative breast cancer patients has not been confirmed.
【作者单位】：吉林大学护理学院外科教研室;吉林大学第一医院乳腺外科;
【基金】：吉林省科技厅科技发展计划项目资助课题(20150101205jc)
【分类号】：R737.9

【相似文献】