Snail在肝内胆管癌中的表达及其临床意义

发布时间：2018-05-19 17:22

本文选题：胆管肿瘤 + 胆管　；参考：《中国普通外科杂志》2017年02期

【摘要】：目的:探讨Snail在肝内胆管癌组织中的表达及其与患者临床病理特征和生存预后的关系。方法:回顾性分析1999年12月—2010年1月外科手术治疗的55例肝内胆管癌病例及随访资料,免疫组织化学检测上述患者癌组织及癌旁组织标本中Snail的表达情况,分析Snail表达与临床病例资料、病理特征及预后的关系。结果:肿瘤组织中Snail表达量(2.764 vs.0.914)与高表达率(48.6%vs.18.0%)均明显高于癌旁组织(均P0.05),且Snail表达与肿瘤分化(χ~2=4.231,P=0.040)、TNM分期(χ~2=6.631,P=0.010)、淋巴结转移(χ~2=4.134,P=0.042)、微血管侵犯(χ~2=10.197,P=0.001)以及复发(χ~2=4.610,P=0.032)有关,与Snail低表达患者比较,Snail高表达患者总体生存率降低(P=0.018)、术后累计复发率升高(P=0.032)。单因素分析与多因素Cox回归模型分析结果示,微血管侵犯、淋巴结转移以及Snail表达是肝内胆管癌患者预后的独立影响因素(均P0.05)。结论:Snail在肝内胆管癌组织中表达增加,且Snail过表达与肝内胆管癌患者恶性病理特征及不良预后密切相关。
[Abstract]:Objective: to investigate the expression of Snail in intrahepatic cholangiocarcinoma and its relationship with clinicopathological features and survival prognosis. Methods: the data of 55 cases of intrahepatic cholangiocarcinoma treated surgically from December 1999 to January 2010 were analyzed retrospectively. The expression of Snail in the tissues and adjacent tissues of these patients was detected by immunohistochemistry. To analyze the relationship between Snail expression and clinical data, pathological features and prognosis. Results: the expression of Snail in tumor tissues was significantly higher than that in paracancerous tissues (P 0.05), and the expression of Snail was correlated with tumor differentiation (蠂 2 / 2.231P ~ (0.040) P ~ (0.040) P ~ (0.010), lymph node metastasis (蠂 ~ (2n) = 4.134P 0.042), microvascular invasion (蠂 ~ 210.197P ~ (0.001) and recurrence (蠂 ~ (24) 610p ~ (0.032). Compared with patients with low expression of Snail, the overall survival rate of patients with high expression of snail was lower than that of patients with low expression of Snail, and the cumulative recurrence rate was higher than that of patients with high expression of Snail. Univariate analysis and multivariate Cox regression analysis showed that microvascular invasion, lymph node metastasis and Snail expression were independent prognostic factors in patients with intrahepatic cholangiocarcinoma (all P 0.05). Conclusion the expression of Snail is increased in intrahepatic cholangiocarcinoma tissues, and the overexpression of Snail is closely related to the malignant pathological features and poor prognosis of patients with intrahepatic cholangiocarcinoma.
【作者单位】：昆明医科大学第二附属医院肝胆外科;
【基金】：国家自然科学基金资助项目(81260084) 云南省科技厅-昆明医科大学联合专项基金资助项目(2015FB056)
【分类号】：R735.8

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