沙利度胺对放射性肺损伤大鼠免疫功能的影响

发布时间：2018-05-19 17:57

本文选题：沙利度胺 + 放射性肺损伤　；参考：《广东医学》2017年06期

【摘要】：目的探讨沙利度胺对放射性肺损伤大鼠免疫功能的影响。方法 100只SD大鼠随机分成沙利度胺组、地塞米松组、单纯照光组、正常组。沙利度胺组、地塞米松组、单纯照光组麻醉后行放疗(6 MV-X线20Gy一次肺部照射),沙利度胺组和地塞米松组照射后分别给予沙利度胺[100 mg/(kg·d)]和地塞米松[1.5 mg/(kg·d)]治疗;单纯照光组和正常组给予等容积生理盐水灌服。照射后第7、15、30、45、60天取材,观察肺组织病理学改变;检测外周血淋巴细胞亚群、NK细胞以及细胞因子白细胞介素(IL)-1、IL-6、肿瘤坏死因子-α(TNF-α)水平。结果沙利度胺组较地塞米松组、单纯照光组病变程度轻,且恢复快,至第60天,沙利度胺组的IL-1、TNF-α、CD3、CD4、CD8均高于单纯照光组和地塞米松组(P0.05),IL-6低于单纯照光组和地塞米松组(P0.05)。结论沙利度胺能提高放射性肺损伤大鼠的免疫功能。
[Abstract]:Objective to investigate the effect of thalidomide on the immune function of rats with radionuclide injury. Methods 100 SD rats were randomly divided into thalidomide group, dexamethasone group, simple illumination group, normal group, thalidomide group, dexamethasone group, radiotherapy after simple illumination group (6 MV- X-ray 20Gy lung irradiation), thalidomide group and dexamethasone group illumination. After irradiation, thalidomide [100 mg/ (kg. D)] and dexamethasone [1.5 mg/ (kg. D)] were treated, and only light group and normal group were given equal volume of normal saline. After irradiation, the material was obtained and the pathological changes of lung tissue were observed. The lymphocyte subsets, NK cells and cytokines (IL) -1 were detected. The level of tumor necrosis factor - alpha (TNF- alpha). Results thalidomide group was less than dexamethasone group. The degree of pathological changes in simple illumination group was light and fast. To sixtieth days, the IL-1, TNF- a, CD3, CD4, CD8 of thalidomide group were higher than those in simple illumination group and dexamethasone group (P0.05), IL-6 was lower than that of simple illumination group and dexamethasone group (P0.05). Conclusion thalidomide can be extracted. The immune function of rats with high radiation-induced lung injury.
【作者单位】：宜春市人民医院肿瘤科;宜春市人民医院康复科;宜春市人民医院呼吸科;宜春市人民医院检验科;
【基金】：宜春市科技计划项目(编号:JXYC2016KSC021)
【分类号】：R730.55

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