转录信号传导子及激活子3在肝内胆管癌中的表达及意义

发布时间：2018-05-20 00:36

本文选题：胆管肿瘤 + 肝内胆管上皮癌　；参考：《第二军医大学学报》2017年02期

【摘要】：目的检测转录信号传导子及激活子3(STAT3)在肝内胆管癌(ICC)中的表达情况,并分析STAT3表达对手术切除后的临床效果及预后的影响。方法采用免疫组织化学法检测ICC组织中STAT3的表达,并分析STAT3表达与临床病理参数之间的关系;采用Pearson χ~2检验和Fisher精确检验分析STAT3表达与其他临床病理参数的关系;采用Kaplan-Meier(KM)法估计和绘制生存曲线,采用log-rank检验进行组间生存曲线的比较;采用Cox危险度回归模型分析临床病理参数和STAT3表达对生存率的影响。结果 ICC组织中STAT3表达较瘤旁组织增加,且与肿瘤体积大、病理性卫星灶、微血管侵犯、肿瘤分化差以及淋巴结转移密切相关。高表达STAT3患者的总体生存期和无瘤生存期更短,预后更差。Cox多因素分析结果发现STAT3高表达是影响总体生存期的独立预后因素。结论 STAT3高表达提示预后较差,是ICC患者预后的独立影响因素,可能成为ICC靶向治疗的潜在靶点。
[Abstract]:Objective to detect the expression of transcriptional signal transducers and activators in intrahepatic cholangiocarcinoma (ICC), and to analyze the effect of STAT3 expression on the clinical outcome and prognosis of patients with intrahepatic cholangiocarcinoma. Methods Immunohistochemical method was used to detect the expression of STAT3 in ICC, and the relationship between STAT3 expression and clinicopathological parameters was analyzed, and the relationship between STAT3 expression and other clinicopathological parameters was analyzed by Pearson 蠂 ~ 2 test and Fisher accurate test. Kaplan-Meierian KM method was used to estimate and draw survival curve, log-rank test was used to compare survival curve between groups, and Cox risk regression model was used to analyze the effect of clinicopathological parameters and STAT3 expression on survival rate. Results the expression of STAT3 in ICC was higher than that in adjacent tissues, and was closely related to tumor size, pathological satellite focus, microvascular invasion, poor differentiation of tumor and lymph node metastasis. The overall survival and tumor-free survival of patients with high expression of STAT3 were shorter and the prognosis was worse. The results of multivariate analysis showed that the high expression of STAT3 was an independent prognostic factor affecting the overall survival. Conclusion the high expression of STAT3 suggests that the prognosis of ICC patients is poor and may be a potential target of ICC targeted therapy.
【作者单位】：第二军医大学东方肝胆外科医院腹腔镜科;第二军医大学东方肝胆研究所信号转导实验室;
【基金】：国家自然科学基金(81372674) 上海市卫生和计划生育委员会基金(20164Y0109) 第二军医大学青年启动基金(2016QN21)~~
【分类号】：R735.8

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