地塞米松联合普萘洛尔治疗面颈部婴幼儿血管瘤疗效研究

发布时间：2018-05-20 07:32

本文选题：婴幼儿血管瘤 + 普萘洛尔　；参考：《遵义医学院》2017年硕士论文

【摘要】：目的:应用地塞米松联合低剂量普萘洛尔与单纯低剂量普萘洛尔治疗婴幼儿面颈部血管瘤进行对比研究,分析其疗效及安全性,同时检测其对血清中血管内皮生长因子(VEGF)的影响。方法:选择2015年2月-2016年11月就诊于遵义医学院附属口腔医院及遵义医学院附属医院小儿外科的32例婴幼儿面颈部血管瘤患儿,年龄在1月~1岁,其中男性15例,女性17例。用药前行血常规、电解质、肝肾功、血糖、凝血功、心脏彩超等检查,常规化验检查无异常者,根据纳入标准采用双色球法随机分为试验组及对照组。每组各16例。试验组采用静滴低剂量地塞米松联合口服普萘洛尔进行治疗,地塞米松用法为静脉滴注,剂量为0.3 mg/kg/d,每日1次,共3日;普萘洛尔用法为口服,剂量为2.0 mg/kg/d,1次/日顿服,疗程为6个月;对照组采用单纯口服普萘洛尔组,剂量为2.0 mg/kg/d,1次/日顿服,疗程6个月。对用药前、用药后6月患儿病变治疗有效率及肝功能、心率指标进行分析,同时检测血清中VEGF水平,分析对血清中VEGF的影响。结果:试验组总体有效率为93.75%,对照组总体有效率为81.25%,两组间具有显著差异(P0.05);治疗后1周,试验组血清VEGF水平下降较对照组大(P0.05);治疗后6月,两组血清中VEGF水平对比无差异(P0.05);治疗前后监测患儿肝功能,两组对比无差异(P0.05);第1日用药前后心率比较,对照组心率有所降低,差异有统计学意义(P0.05),第2日用药2h时,患儿心率变化无差异(P0.05)。试验组于用药前后心率对比无差异(P0.05)。结论:低剂量糖皮质激素联合低剂量普萘洛尔治疗婴幼儿血管瘤,疗效优于单纯使用低剂量普萘洛尔的治疗。其安全性与单纯低剂量普萘洛尔治疗婴幼儿血管瘤无差别。
[Abstract]:Objective: to compare the efficacy and safety of dexamethasone combined with low dose propranolol and low dose propranolol in the treatment of facial and cervical hemangioma in infants. At the same time, the effect of VEGF on serum vascular endothelial growth factor (VEGF) was detected. Methods: from February 2015 to November 2016, 32 infants with facial and neck hemangioma were selected from the Department of Pediatric surgery, affiliated Stomatology Hospital of Zunyi Medical College and affiliated Hospital of Zunyi Medical College, aged 1 year old, including 15 males and 17 females. Blood routine, electrolytes, liver and kidney function, blood sugar, coagulation function, heart color Doppler examination, and routine laboratory examination were not abnormal before medication. According to the inclusion standard, they were randomly divided into test group and control group. There were 16 cases in each group. The experimental group was treated by intravenous drip of low dose dexamethasone combined with oral propranolol. Dexamethasone was given intravenously at a dose of 0.3 mg / kg / d once a day for 3 days, and propranolol was given orally at a dose of 2.0 mg / kg / d per day. The course of treatment was 6 months, while the control group was treated with oral propranolol at a dose of 2.0 mg / kg 路d ~ (-1) per day for 6 months. The effective rate, liver function and heart rate were analyzed before and 6 months after treatment. The serum VEGF level was detected and the effect on serum VEGF was analyzed. Results: the total effective rate of the trial group was 93.75 and the total effective rate of the control group was 81.25. There was a significant difference between the two groups, and the serum VEGF level in the experimental group was significantly lower than that in the control group at 1 week after treatment. There was no difference in serum VEGF level between the two groups (P 0.05), monitoring of liver function before and after treatment, and no difference between the two groups (P 0.05). The heart rate of the control group was lower than that of the control group before and after the treatment on the first day, and the difference was statistically significant at 2 h after treatment. There was no difference in heart rate change in children (P 0.05). There was no difference in heart rate before and after treatment in the test group (P 0.05). Conclusion: low dose glucocorticoid combined with low dose propranolol is superior to low dose propranolol in the treatment of infantile hemangioma. There was no difference between low dose propranolol and low-dose propranolol in the treatment of infantile hemangioma.
【学位授予单位】：遵义医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R732.2

【相似文献】