Meta分析近十年腹腔镜直肠癌术后吻合口瘘的危险因素

发布时间：2018-05-22 19:56

  本文选题：腹腔镜 + 直肠癌　； 参考：《山西医科大学》2017年硕士论文

【摘要】：目的:本文通过meta分析,系统性地分析了近十年来腹腔镜下直肠癌切除术后吻合口瘘的危险因素,更好地为临床上的治疗提供决策。方法:根据纳入与排除标准,系统检索英文数据库(Pub Med、Embase、The Cochrane Library)和中文数据库(中国知网、万方数据库)中关于分析腹腔镜直肠癌术后吻合口瘘危险因素队列研究的相关文献,检索时间设置为2007年1月至2017年1月,经过浏览题目、摘要及全文后,筛出符合纳入标准的高质量文献,摘录其中数据。运用Review Manager 5.3进行Meta分析。结果:最终19篇文献入选本次Meta分析,总样本量8422例,总体吻合口瘘发生率5.88%(495/8422)。Meta分析结果显示:性别[合并OR值2.41,95%CI(1.93-3.00),P0.00001];术前白蛋白[合并OR值0.59,95%CI(0.38-0.90),P=0.01];糖尿病[合并OR值1.48,95%CI(1.06-2.07),P=0.02];术前BMI[合并OR值1.64,95%CI(1.01-2.65),P=0.005];术前新辅助放化疗[合并OR值1.73,95%CI(1.27-2.36),P=0.0005];肿瘤距肛缘距离[合并OR值0.60,95%CI(0.46-0.77),P0.0001];肿瘤大小[合并OR值2.10,95%CI(1.35-3.27),P=0.001]。结论:男性、术前白蛋白3.5mg/d L、术前合并糖尿病、BMI≥25kg/m2、术前行新辅助放化疗、肿瘤距肛缘距离≤7厘米和肿瘤直径≥5厘米是腹腔镜下直肠癌术后吻合口瘘的重要危险因素
[Abstract]:Objective: to systematically analyze the risk factors of anastomotic leakage after laparoscopic resection of rectal cancer in recent ten years by meta analysis. Methods: according to the criteria of inclusion and exclusion, we systematically searched the English database Pub Medbase, the Cochrane Library, and the Chinese database, which were related to the cohort study on the risk factors of anastomotic fistula after laparoscopic rectal cancer surgery. The retrieval time was set from January 2007 to January 2017. After browsing the title, summary and full text, the high quality documents which met the inclusion criteria were selected and the data were extracted. Review Manager 5.3 was used for Meta analysis. Results: the final 19 articles were included in this Meta analysis. The total sample size was 8422 cases. 鎬讳綋鍚诲悎鍙ｇ槝鍙戠敓鐜，

本文编号：1923399