浸润性肺腺癌中Aurora-A和基质金属蛋白酶-9的表达

发布时间：2018-05-24 18:20

本文选题：肺腺癌 + Aurora-A激酶　；参考：《中国老年学杂志》2017年24期

【摘要】：目的应用免疫组化SP法检测浸润性肺腺癌中Aurora-A激酶(Aurora-A)和基质金属蛋白酶(MMP)-9的表达特征,分析二者在不同临床病理特征中的表达意义。方法确诊为浸润性肺腺癌51例为观察组,确诊为原位腺癌21例为对照组,收集距肿瘤边缘5 cm的非肿瘤性的肺组织20例为正常对照组,均留取术后蜡块组织,应用免疫组化SP法检测3组Aurora-A和MMP-9表达,分析其在不同临床病理特征中的差别。结果3组Aurora-A和MMP-9表达阳性率差异显著(P0.01)。观察组Aurora-A和MMP-9表达阳性率与肿瘤脉管累犯和转移密切相关。Aurora-A表达阳性率与肿瘤增殖指数和最大径密切相关。相关分析显示观察组Aurora-A和MMP-9表达呈正相关。结论 Aurora-A和MMP-9在浸润性肺腺癌中的表达升高是促进肿瘤形成和进展的重要因素。Aurora-A和MMP-9具有一定正向协同作用。
[Abstract]:Objective to detect the expression of Aurora-A kinase Aurora-A) and matrix metalloproteinase-9 (MMP-9) in invasive lung adenocarcinoma by immunohistochemical SP method and to analyze their significance in different clinicopathological features. Methods 51 cases of invasive lung adenocarcinoma were diagnosed as observation group, 21 cases were diagnosed as control group, and 20 cases of nonneoplastic lung tissue 5 cm from the margin of tumor were collected as normal control group. Immunohistochemical SP method was used to detect the expression of Aurora-A and MMP-9 in three groups, and their differences in different clinicopathological features were analyzed. Results the positive rates of Aurora-A and MMP-9 were significantly different among the three groups (P 0.01). The positive rate of Aurora-A and MMP-9 expression was closely related to tumor vascular recurrence and metastasis. The positive rate of Aurora-A expression was closely related to tumor proliferation index and maximum diameter. Correlation analysis showed that there was a positive correlation between Aurora-A and MMP-9 expression in observation group. Conclusion the increased expression of Aurora-A and MMP-9 in invasive lung adenocarcinoma is an important factor to promote tumor formation and progression. Aurora-A and MMP-9 have positive synergistic effects.
【作者单位】：齐齐哈尔医学院附属第三医院胸外科;
【基金】：齐齐哈尔市科学技术计划项目(SF2D-2012067)
【分类号】：R734.2

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