CD133和p53在结直肠癌中的表达及临床意义

发布时间：2018-05-26 13:17

本文选题：结直肠癌 + 肿瘤干细胞　；参考：《实用医学杂志》2017年16期

【摘要】：目的探讨结直肠癌组织中CD133和p53蛋白的表达及临床病理意义。方法采用免疫组化方法检测74例结直肠癌组织中CD133和p53蛋白的表达情况,并分析其与结直肠癌临床病理参数及预后的关系。结果 CD133和p53蛋白的表达阳性率分别为33.8%和55.4%,二者表达阳性率与结直肠癌患者年龄、性别、肿瘤发生部位及组织学类型均无关(P0.05),而与分化程度、TNM分期及是否发生远处转移有关,差异均有统计学意义(P0.05)。Spearman相关性分析结果显示CD133和p53的表达并无相关性。结论 CD133和p53的表达与结直肠癌分化程度及TNM分期密切相关,可作为评价结直肠癌恶性生物学行为、诊疗及预后的重要生物标志物。
[Abstract]:Objective to investigate the expression of CD133 and p53 protein in colorectal carcinoma and its clinicopathological significance. Methods Immunohistochemical method was used to detect the expression of CD133 and p53 protein in 74 cases of colorectal cancer, and the relationship between the expression of CD133 and p53 protein and clinicopathologic parameters and prognosis of colorectal cancer was analyzed. Results the positive rates of CD133 and p53 were 33.8% and 55.4%, respectively. The positive rates of CD133 and p53 were not related to age, sex, location and histological type of colorectal cancer, but related to the stage of differentiation and the distant metastasis. There was no correlation between the expression of CD133 and p53. Conclusion the expression of CD133 and p53 is closely related to the differentiation degree and TNM stage of colorectal cancer, and can be used as an important biomarker for evaluating malignant biological behavior, diagnosis and treatment and prognosis of colorectal cancer.
【作者单位】：南方医科大学南方医院肿瘤内科;广州医科大学附属第三医院消化内科;广州医科大学附属第一医院消化内科;南方医科大学南方医院消化内科;
【基金】：国家自然基金青年项目(编号:81603477) 国家消化系统疾病临床医学研究中心科技支撑项目(编号:2015BAI13B07)
【分类号】：R735.34

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