肾透明细胞癌组织ICAM1表达临床意义探讨

发布时间：2018-05-26 19:32

  本文选题：细胞间黏附分子- + 免疫组织化学　； 参考：《中华肿瘤防治杂志》2017年12期

【摘要】：目的细胞间黏附分子-1(intercellular cell adhesion molecule-1,ICAM1)在多种恶性肿瘤中都发挥着重要作用,但其对肾透明细胞癌(clear-cell renal cell carcinoma,ccRCC)的影响鲜见报道。本研究旨在探讨ICAM1在ccRCC预后判断以及早期诊断中的意义。方法随机选择2000-01-18-2010-09-08皖南医学院弋矶山医院ccRCC手术冷冻标本173例,利用免疫组织化学(immunohistochemistry,IHC)方法检测ICAM1在ccRCC中的表达,并分析ICAM1表达与临床病理参数的相关性。应用生存分析研究ICAM1表达对ccRCC患者肿瘤特异生存率(cancer-specific survival,CSS)的影响。通过计算受试者工作特征曲线(receiver operating charccteristic curve,ROC)下的面积(area under the ROC curve,AUC)来评价ICAM1表达对ccRCC早期诊断的价值。结果173例ccRCC标本组织中,ICAM1阳性率为83.2%(144/173);173例对应的癌旁正常肾小管上皮组织中,ICAM1均为阴性。ICAM1在男性(χ~2=9.208,P=0.002)、T3/T4期(χ~2=5.207,P=0.022)、非N0M0期(χ~2=4.306,P=0.038)以及肾盂侵犯(χ~2=4.124,P=0.042)等亚组中高表达率分别为56.9%(74/130)、65.9%(27/41)、75.0%(12/16)和67.9%(19/28),均高于对照组,差异有统计学意义。Kaplan-Meier生存分析提示,ICAM1高表达时,ccRCC患者的CSS显著下降(P0.001),5和10年累积CSS与ICAM1低表达患者相比,分别下降了21.6%和14.1%。Cox回归分析提示,ICAM1是判断ccRCC患者CSS的独立预测因子,P=0.005。ICAM1在ccRCC早期诊断中的AUC值为0.916,P0.001。结论 ICAM1高表达时,ccRCC患者预后差,ICAM1是判断ccRCC患者预后的独立预测因子,并且可能成为ccRCC早期诊断的潜在标志物。
[Abstract]:Objective Intercellular cell adhesion molecule-1 (ICAM1) plays an important role in many kinds of malignant tumors, but its effect on clear cell renal cell carcinoma (CCCC) is rarely reported. The purpose of this study was to investigate the significance of ICAM1 in early diagnosis and prognosis of ccRCC. Methods 173 frozen specimens of ccRCC were randomly selected from Yaji Mountain Hospital of Southern Anhui Medical College from January 18 to August 2010. Immunohistochemistry was used to detect the expression of ICAM1 in ccRCC, and the correlation between the expression of ICAM1 and clinicopathological parameters was analyzed. Survival analysis was used to study the effect of ICAM1 expression on tumor-specific survival rate (ccRCC) in patients with ccRCC. The value of ICAM1 expression in the early diagnosis of ccRCC was evaluated by calculating the area under the ROC under receiver operating charccteristic curveout. 缁撴灉173渚媍cRCC鏍囨湰缁勭粐涓，

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