FGFR1基因扩增与非小细胞肺癌的相关性研究

发布时间：2018-05-26 20:10

  本文选题：非小细胞肺癌 + FGFR1　； 参考：《济南大学》2017年硕士论文

【摘要】：目的:检测FGFR1基因在NSCLC病理组织中基因扩增情况,研究FGFR1基因扩增与NSCLC患者临床特征之间的关系,为非小细胞患者的靶向治疗提供理论依据。方法:采用荧光原位杂交(FISH)技术检测147例非小细胞肺癌组织的FGFR1基因扩增的情况,应用SPSS 22.0统计软件进行数据处理,了解FGFR1基因扩增的影响因素及临床特征。结果:(1)肺鳞癌组织中FGFR1基因扩增率为15.9%,肺腺癌组织中FGFR1基因扩增率为5.4%,其它亚型中未发现FGFR1基因扩增。肺鳞癌患者FGFR1基因扩增率显著高于肺腺癌患者及其他非小细胞肺癌患者,差异有统计学意义(p=0.026)。(2)在性别方面,FGFR1基因扩增在男女患者中无统计学差异;在年龄方面,以65岁为界点,两组间FGFR1基因扩增在不同年龄段的患者中无统计学差异;在肿瘤大小方面,以肿瘤直径3cm为界点,两组间FGFR1基因扩增在不同肿瘤直径间无统计学差异;在肿瘤TNM分期方面,两组间FGFR1基因扩增在Ⅰ-Ⅱ期与Ⅲ-Ⅳ期不同分期的患者中亦无统计学差异;在外周器官转移与否方面,两组间FGFR1基因扩增同样无统计学差异;在吸烟与否方面,吸烟组FGFR1基因扩增明显高于未吸烟组,差异具有统计学意义。结论:(1)FGFR1基因在NSCLC中存在扩增,肺鳞癌患者FGFR1基因扩增率显著高于肺腺癌及其它非小细胞肺癌类型患者。(2)FGFR1基因扩增与性别、年龄、肿瘤大小、TNM分期、外周器官转移与否均无显著无关,但与患者吸烟状况有关。(3)FGFR1基因扩增可能成为肺鳞癌患者靶向治疗中的靶点之一。
[Abstract]:Objective: to detect the amplification of FGFR1 gene in the pathological tissues of NSCLC, to study the relationship between the amplification of FGFR1 gene and the clinical characteristics of NSCLC patients, and to provide a theoretical basis for the targeted therapy of non-small cell patients. Methods: fluorescence in situ hybridization (fish) technique was used to detect the amplification of FGFR1 gene in 147 cases of non-small cell lung cancer (NSCLC). The data were processed by SPSS 22.0 software to understand the influencing factors and clinical characteristics of FGFR1 gene amplification. Results the amplification rate of FGFR1 gene was 15.9in lung squamous cell carcinoma, 5.4in adenocarcinoma and 5.4in lung adenocarcinoma. No amplification of FGFR1 gene was found in other subtypes. The amplification rate of FGFR1 gene in patients with lung squamous cell carcinoma was significantly higher than that in patients with lung adenocarcinoma and other non-small cell lung cancer. There was no significant difference in FGFR1 gene amplification between the two groups in different age groups; in tumor size, there was no significant difference between the two groups in tumor diameter 3cm amplification; in tumor TNM staging, there was no significant difference between the two groups. There was no significant difference in the amplification of FGFR1 gene between the two groups in different stages of stage 鈪，

本文编号：1938740