GSTM1基因多态性与白血病关系的研究

发布时间：2018-05-27 18:34

本文选题：白血病 + GSTM基因　；参考：《中国实验血液学杂志》2017年02期

【摘要】：目的:探讨白血病患者GSTM1基因多态性与白血病疗效及主要生物学特征的关系。方法:采用巢式PCR检测GSTM1基因型,比较不同基因型患者第1疗程的缓解率及发病时的主要生物学特征。结果:GSTM1非缺失基因型患者第1疗程的缓解率及部分缓解率与GSTM1缺失基因型无显著性差异(χ~2=0.290,P=0.590);GSTM1基因型与患者性别、年龄,初诊时白细胞数、血红蛋白水平、血小板数、脾脏肿大无相关性(P0.05);用Log-rank法对GSTM1缺失基因型的AML与ALL组比较结果显示,AML与ALL组患者的生存率之间无统计学差异(χ~2=2.043,P=0.153);GSTM1未缺失基因型患者初诊时血清乳酸脱氢酶浓度与GSTM1缺失基因型比较有统计学差异(P=0.001)。结论:GSTM1基因型与白血病患者第1疗程的缓解及部分缓解率无相关性,GSTM1基因型与患者血清乳酸脱氢酶浓度有关。
[Abstract]:Objective: to investigate the relationship between GSTM1 gene polymorphism and the efficacy and biological characteristics of leukemia. Methods: nested PCR was used to detect GSTM1 genotypes. The remission rate and the main biological characteristics of patients with different genotypes in the first course of treatment were compared. Results there was no significant difference in remission rate and partial remission rate between non-deletion genotype and GSTM1 deletion genotype in the first course of treatment (蠂 ~ (2 / 2) 0.290 ~ (0.290) and sex, age, white blood cell count, hemoglobin level and platelet count in patients with GSTM1. There was no correlation between splenomegaly and splenomegaly (P0.05A). The results showed that there was no significant difference between the survival rate of AML patients with GSTM1 deletion genotype and that of ALL group (蠂 ~ 2 / 2 043 ~ 0. 043) and the serum lactate dehydrogenase concentration and the level of lactate dehydrogenase (LDH) in GSTM1 / GSTM1 patients at first visit. The genotypes of GSTM1 deletion were significantly different (P < 0. 001). Conclusion there is no correlation between the proportion of GSTM1 genotype and the remission and partial remission rate of leukemia patients in the first course of treatment. There is no correlation between the GSTM1 genotype and serum lactate dehydrogenase concentration.
【作者单位】：兰州大学第一医院中心实验室;兰州大学第一医院血液科;
【基金】：兰州市自然科学基金(2011-2-46)
【分类号】：R733.7

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