抑癌DNA甲基化在乳腺癌早期筛查和辅助诊断中的价值比较:间接比较Meta分析

发布时间：2018-05-28 01:06

本文选题：乳腺癌 + 甲基化　；参考：《首都医科大学学报》2017年04期

【摘要】：目的本研究利用间接比较Meta分析的方法评价在乳腺癌中众多甲基化的基因中价值较大的基因。方法计算机检索Cochrane Library、Pub Med、EMbase、Chinese Bio Medical Literature Database(CBM)、Web of Science、中国知网(China National Knowledge Infrastructure,CNKI)和万方数据库,收集涉及抑癌基因启动子甲基化与乳腺癌关系的Meta研究。采用间接比较Meta分析的方法评价在乳腺癌病人中甲基化的抑癌基因的诊断价值。结果最终共纳入10个甲基化基因(10个Meta研究),共计130个原始研究。在汇总的Meta分析中,甲基化的同源性磷酸酶-张力蛋白基因(phosphatase and tensin homolog,PTEN)比值比[odds ratio(OR)=66.16(24.48~178.82)]、人类相关转录因子基因(Runt-related transcription factor 3,RUNX3)[OR=28.88(15.48~54.25)]对乳腺癌的风险最大,虽然乳腺癌1号基因(breast cancer 1,BRCA1)[OR=2.11(1.88~2.35)]最小,但是在10个Meta研究中BRCA1的权重是57.1%。根据灵敏度相比之下,RUNX3基因[0.62(0.56~0.67)]最大,其次是脆性组氨酸三联体基因(fragile histidine triad protein,FHIT)[0.59(0.54~0.63)],但是RUNX3基因的特异度[0.95(0.91~0.97)]大于FHIT基因[0.65(0.61~0.69)]。综合甲基化基因的灵敏度和特异度,利用间接比较的方法,RUNX3基因对乳腺癌的诊断价值最大。结论在乳腺癌的早期筛查和辅助检查中,提倡对RUNX3和BRCA1甲基化的基因加以利用。
[Abstract]:Objective to evaluate the genes of large number of methylated genes in breast cancer by indirect comparison of Meta analysis. Methods Cochrane Library, Pub Med, EMbase, Chinese Bio Medical Literature Database (CBM) were evaluated by computer. The Meta study involved in the relationship between tumor suppressor promoter methylation and breast cancer was collected in a square database. The diagnostic value of methylation tumor suppressor genes in breast cancer patients was evaluated by indirect comparison of Meta analysis. The results were finally included in 10 methylation genes (10 Meta Studies), a total of 130 original studies. A summary of Meta analysis The ratio of phosphatase and tensin homolog (PTEN) to methylation is higher than [odds ratio (OR) =66.16 (24.48~178.82)], and the human related transcription factor gene (Runt-related transcription 3) is the most risky for breast cancer, although breast cancer No. 1 1, BRCA1) [OR=2.11 (1.88~2.35)] minimum, but in the 10 Meta studies, the weight of BRCA1 is 57.1%. based on sensitivity, the RUNX3 gene [0.62 (0.56~0.67)] is the largest, followed by the fragile histidine three associated gene (fragile histidine triad). T gene [0.65 (0.61~0.69)]. The sensitivity and specificity of the integrated methylation gene. The RUNX3 gene is of the greatest value in the diagnosis of breast cancer by indirect comparison. Conclusion in the early screening and auxiliary examination of breast cancer, the gene for RUNX3 and BRCA1 methylation is advocated.
【作者单位】：首都医科大学公共卫生学院流行病与卫生统计学系临床流行病学北京市重点实验室;
【基金】：国家自然科学基金(81673247,81370083,81530087) 北京市科技新星项目(Z141107001814058)~~
【分类号】：R737.9

【参考文献】