97例胃肠胰神经内分泌肿瘤临床特征与预后分析

发布时间：2018-05-28 00:49

本文选题：肿瘤 + 疾病特征　；参考：《中华疾病控制杂志》2017年08期

【摘要】：目的探讨胃肠胰神经内分泌肿瘤(gastroenteropancreatic neuroendocrine neoplasms,GEP-NEN)的临床特征以及预后,为进一步认识该病提供帮助。方法回顾性分析2011年12月~2015年12月期间由安徽医科大学第一附属医院收治的97例GEP-NEN患者的临床以及随访资料。结果 97例患者中,男性患者数量为女性患者1.9倍(64∶33)。发病部位最常见于胃(40.2%)和直肠(25.8%)。GEP-NEN缺乏特异性症状,其主要症状还是腹痛、腹胀等消化道一般常见症状。肿瘤标记物嗜铬颗粒蛋白A和突触素的阳性率高,分别为87.6%、96.9%。Cox比例风险回归分析中,发现除常见的肿瘤分级、浸润深度及淋巴转移是GEP-NEN患者生存的影响因素外(均有P0.05),性别及不同的手术方式对患者预后也有影响(均有P0.05)。结论 GEP-NEN是一种少见的疾病,消化道任何部位均可出现,临床表现没有特异性,给术前诊断带来困难,很多病例确诊时已是晚期。治疗以手术为主,总体预后较好。随访1、3年生存率分别为81.9%和63.4%。
[Abstract]:Objective to investigate the clinical features and prognosis of gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) in gastrointestinal and pancreatic neuroendocrine tumors. Methods the clinical and follow-up data of 97 patients with GEP-NEN admitted from the first affiliated Hospital of Anhui Medical University from December 2011 to December 2015 were retrospectively analyzed. Results among 97 patients, the number of male patients was 1.9 times that of female patients. The site of the disease is the most common in the stomach (40.2) and the rectal tract 25.88.GEP-NEN is lack of specific symptoms, the main symptoms are abdominal pain, abdominal distention and other common symptoms of the digestive tract. The positive rates of chromaffin A and synaptophysin were 87.6% and 96.9% respectively in the Cox proportional risk regression analysis. The depth of invasion and lymphatic metastasis were the other factors influencing the survival of GEP-NEN patients (all P 0.05). Gender and different surgical methods also had influence on the prognosis of patients with GEP-NEN (P 0.05). Conclusion GEP-NEN is a rare disease, which can be seen anywhere in the digestive tract. The clinical manifestation is not specific, which brings difficulties to preoperative diagnosis, and many cases are diagnosed at the late stage. Surgery is the main treatment, and the overall prognosis is good. The 1-year and 3-year survival rates were 81.9% and 63.4%, respectively.
【作者单位】：安徽医科大学第一附属医院普外科二病区;
【分类号】：R735

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