肺癌合并眼部转移:单中心回顾性研究并文献综述

发布时间：2018-05-30 12:03

本文选题：肺肿瘤 + 眼部肿瘤　；参考：《中国肺癌杂志》2017年05期

【摘要】：背景与目的眼部转移(ocular metastasis)是肺癌少见转移之一,影响患者生活质量。本研究旨在探讨肺癌合并眼转移患者的临床特征及预后。方法回顾性分析肺癌合并眼部转移9例患者的临床资料,回顾近10年文献报道共42例患者的临床特点。结果 9例患者的中位年龄为51岁(范围:41岁-61岁),其中7例诊断为非小细胞肺癌(包括腺癌6例);1例为小细胞肺癌;1例病理不详。眼转移部位方面,脉络膜8例,虹膜1例。文献回顾中,小细胞肺癌占21.4%(n=9),腺癌占47.6%(n=20),脉络膜是最常见的眼转移部位(66.7%,n=28)。肺癌合并眼转移患者,系统化疗的疾病控制率仅为28%,联合眼部局部治疗可有效控制眼部症状。结论肺癌合并眼部转移以肺腺癌多见,脉络膜转移是肺癌眼部转移的最常见转移部位。眼部局部治疗可控制局部症状,但系统性化疗疗效差。
[Abstract]:Background and objective: ocular metastasis is one of the rare metastases of lung cancer, which affects the quality of life of patients. The purpose of this study was to investigate the clinical features and prognosis of patients with lung cancer complicated with ocular metastasis. Methods the clinical data of 9 patients with lung cancer complicated with ocular metastasis were retrospectively analyzed. Results the median age of 9 patients was 51 years old (range: 41 to 61 years old), of which 7 cases were diagnosed as non-small cell lung cancer (including 6 cases of adenocarcinoma and 1 case of small cell lung cancer). There were 8 cases of choroid and 1 case of iris. In literature review, small cell lung cancer accounted for 21. 4%, adenocarcinoma was 47. 6% and choroid was the most common location of ocular metastasis. In patients with lung cancer complicated with ocular metastasis, the disease control rate of systemic chemotherapy is only 28%, combined with local ocular therapy can effectively control ocular symptoms. Conclusion Lung cancer with ocular metastasis is more common in lung adenocarcinoma. Choroidal metastasis is the most common metastatic site of lung cancer. Local ophthalmic treatment can control local symptoms, but systemic chemotherapy is not effective.
【作者单位】：中国医学科学院北京协和医学院呼吸内科;中国医学科学院北京协和医学院风湿免疫科;
【分类号】：R734.2

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