FAK在胸腺上皮肿瘤中的表达及临床意义

发布时间：2018-05-31 13:07

本文选题：FAK + 胸腺上皮肿瘤　；参考：《青岛大学》2017年硕士论文

【摘要】：目的:局部粘着斑激酶(FAK)很长时间以来一直被认为是一个调节生长因子受体和整合素所介导信号的关键性调节蛋白,并且它在肿瘤细胞中通过其激酶活性和脚手架功能起着举足轻重的作用。FAK表达上调和其活性增加已经在不同来源的肿瘤中被证实,并且通常与这些肿瘤的不良的生存预后息息相关。然而,到目前为止,尚且未有对FAK在胸腺上皮肿瘤中的异常表达的报道。本研究的目的是观察FAK在胸腺上皮肿瘤中的表达情况,并探讨FAK的临床意义。方法:我们应用了免疫组织化学方法分析了FAK单克隆抗体4.47在100例福尔马林固定、石蜡包埋的人类胸腺上皮肿瘤标本中的表达情况。并且分析了FAK的表达情况与临床病理参数(性别、年龄、肿瘤大小、重症肌无力、WHO分类,Masaoka-Koga分期)之间的相关性。结果:同正常胸腺组织相比,FAK明显表达在胸腺上皮肿瘤中(P0.001)。此外,FAK的过量表达与高分期(III期,IV期;P0.001)以及高侵袭性亚型(B2、B3型胸腺瘤和胸腺癌;P0.001)有显著的相关性。除此之外,通过使用单因素生存分析发现,FAK的过量表达与较差的10年总生存率显著相关(P0.001)。而且使用多变量分析发现,FAK过量表达是胸腺上皮肿瘤病人的预后的独立因素(P=0.034)。结论:我们的研究结果表明,FAK在胸腺上皮肿瘤发生和进展中起重要作用。FAK可作为胸腺上皮肿瘤的预后标志物,而且FAK是胸腺上皮肿瘤的一个潜在的靶向药物治疗的靶点。
[Abstract]:Objective: local adhesion kinases (FAKs) have long been considered as a key regulatory protein to regulate signal mediated by growth factor receptors and integrins. And it plays an important role in tumor cells through its kinase activity and scaffolding function. The up-regulation of FAK expression and the increase of its activity have been confirmed in different tumor sources. And often associated with poor survival and prognosis of these tumors. So far, however, no abnormal expression of FAK has been reported in thymic epithelial tumors. The purpose of this study was to observe the expression of FAK in thymic epithelial tumors and to explore the clinical significance of FAK. Methods: immunohistochemical method was used to analyze the expression of FAK monoclonal antibody 4.47 in 100 formalin fixed and paraffin embedded human thymic epithelial tumors. The correlation between the expression of FAK and the clinicopathologic parameters (sex, age, tumor size, Masaoka-Koga stage of myasthenia gravis) was analyzed. Results: compared with the normal thymus tissues, the expression of FAK in thymic epithelial tumors was significantly higher than that in normal thymus tissues (P 0.001). In addition, the overexpression of FAK was significantly correlated with P0.001 (P0.001), Thymoma and Thymoma (P0.001) with high invasive subtype B _ 2, B _ 2 and B _ (3). In addition, by using univariate survival analysis, it was found that the overexpression of FAK was significantly correlated with the poor overall 10-year survival rate (P 0.001). Multivariate analysis showed that overexpression of FAK was an independent prognostic factor in patients with thymic epithelial tumors. Conclusion: our results suggest that FAK plays an important role in the development and progression of thymic epithelial tumors. FAK can be used as a prognostic marker of thymic epithelial tumors, and FAK is a potential target of drug therapy for thymoepithelial tumors.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R736.3

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