常用肿瘤标志物在上皮性卵巢癌诊断中的临床价值

发布时间：2018-06-01 02:23

本文选题：肿瘤标志物 + 联合检测　；参考：《中国现代医学杂志》2017年15期

【摘要】：目的研究常用肿瘤标志物糖链抗原(CA125和CA199)、人附睾蛋白4(HE4)、乳酸脱氢酶(LDH)单项及联合检测在上皮性卵巢癌诊断中的临床价值。方法用化学发光微粒子免疫检测法和酶速率法检测220例上皮性卵巢癌患者、78例卵巢上皮性交界性肿瘤患者、120例卵巢成熟性畸胎瘤患者及162例卵巢子宫内膜异位症患者血清中肿瘤标志物浓度。结果 (1)上皮性卵巢癌组的CA125、CA199、HE4及LDH高于其他3组(P0.008);(2)4种肿瘤标志物中HE4诊断上皮性卵巢癌的敏感性为73.18%,特异性为98.89%,约登指数(Youden index)为72.07%,受试者工作特征曲线(ROC曲线)下面积为0.952,综合其他评价指标,可得出HE4的诊断能力最好;(3)联合检测组中CA125、CA199、HE4及LDH四项联合检测诊断上皮性卵巢癌的敏感性为97.73%,特异性为25.00%,ROC曲线下面积为0.973,其诊断价值最高。结论 CA125、CA199、HE4及LDH 4项联合检测是诊断上皮性卵巢癌比较理想的肿瘤标志物组合,对卵巢良恶性肿瘤的鉴别诊断具有重要临床价值。
[Abstract]:Objective to study the clinical value of single and combined detection of carbohydrate chain antigen CA125 and CA199, human epididymal protein 4H4, lactate dehydrogenase (LDH) in the diagnosis of epithelial ovarian cancer. Methods the chemiluminescence microparticle immunoassay and enzyme rate assay were used to detect 220 cases of epithelial ovarian cancer and 78 cases of ovarian epithelial sexual intercourse borderline tumor. 120 cases of ovarian mature teratoma and 162 cases of ovarian endometriosis were detected. Serum tumor markers in patients. Results (1) the sensitivity of HE4 in diagnosis of epithelial ovarian cancer was 73.18, the specificity was 98.89 and the Jordan index (Youden index) was 72.07. The sensitivity of HE4 in diagnosing epithelial ovarian cancer was 73.18, the Youden index was 72.07, and the operating characteristic curve (ROC) was higher than that in the other three groups (P 0.008). The area under it is 0.952. It can be concluded that the diagnostic ability of HE4 is the best. In the combined detection group, the sensitivity of CA125, CA199HE4 and LDH in the diagnosis of epithelial ovarian cancer is 97.73 and the specificity is 25.00. The area under the ROC curve is 0.973.The diagnostic value is the highest. Conclusion the combined detection of CA125, CA199HE4 and LDH is an ideal combination of tumor markers for the diagnosis of epithelial ovarian cancer, and has important clinical value in the differential diagnosis of benign and malignant ovarian tumors.
【作者单位】：新疆医科大学附属肿瘤医院;
【分类号】：R737.31

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