术后血清肿瘤标记物CEA及CA199水平对于预测胃癌复发的价值

发布时间：2018-06-01 20:53

本文选题：胃癌 + 肿瘤标记物　；参考：《吉林大学》2015年硕士论文

【摘要】：目的：评估术后血清肿瘤标记物水平，对于胃癌术后复发转移的诊断价值。材料和方法：我们回顾性的分析了2007年9月－2012年9月就诊于吉大一院胃肠外科的1651例胃癌患者，其中1480例患者接受根治性外科手术治疗，170例患者术后2年内出现复发转移，对术后血清肿瘤标记物水平与胃癌术后复发转移的关系进行分析。结果：血清肿瘤标记物CA199和CEA在5项肿瘤标记物中对于胃癌术后复发及转移有较高的敏感性及特异性。其中CEA对于预测肿瘤复发敏感性及特异性分别为40.6%及89.5%，CA199对于预测肿瘤复发及转移敏感性及特异性分别为34.2%及93.6%。通过调整CA199的临界值，能提高肿瘤标记物对于术后肿瘤复发预测的敏感性。但调整CEA的临界值值却没有相同的效果。结论：在5种肿瘤标记物中，肿瘤标记物CEA及CA199对于胃癌术后复发转移的预测有较高的特异性及敏感性，，通过调整CA199的临界值能提高肿瘤标记物对于预测胃癌复发的敏感性。
[Abstract]:Objective: to evaluate the value of serum tumor markers in the diagnosis of postoperative recurrence and metastasis of gastric cancer. Materials and methods: we retrospectively analyzed 1651 patients with gastric cancer who were treated in gastrointestinal surgery from September 2007 to September 2012, 1480 of whom were treated with radical surgical treatment, 170 patients had recurrence and metastasis within 2 years after operation. The relationship between serum tumor markers and recurrence and metastasis of gastric cancer after operation was analyzed. Results: serum tumor markers CA199 and CEA had high sensitivity and specificity for recurrence and metastasis of gastric cancer. The sensitivity and specificity of CEA for predicting tumor recurrence were 40.6% and 89.5% respectively. The sensitivity and specificity of CA199 for predicting tumor recurrence and metastasis were 34.2% and 93.6g respectively. By adjusting the critical value of CA199, the sensitivity of tumor markers to the prediction of postoperative tumor recurrence can be improved. But adjusting the critical value of CEA does not have the same effect. Conclusion: among the five tumor markers, tumor markers CEA and CA199 have high specificity and sensitivity in predicting recurrence and metastasis of gastric cancer after operation. The sensitivity of tumor markers to predicting recurrence of gastric cancer can be improved by adjusting the critical value of CA199.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R735.2

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