miR-181a与乳腺癌关系的研究进展

发布时间：2018-06-01 21:28

本文选题：乳腺癌 + miR-a　；参考：《首都医科大学学报》2017年04期

【摘要】：微小RNA(microRNAs,miRNAs)是一类高度保守的非编码单链RNA,通过与靶基因mRNA的3'非编码区特异性结合,在转录后水平沉默靶基因表达,从而发挥着功能。一些研究表明miR-181a的表达与肿瘤密切相关,对肿瘤的形成、侵袭及转移起着很重要的作用。miR-181a在乳腺癌中的作用,目前还有诸多争议,一些研究表明miR-181a具有抑癌基因的作用,而另一些研究发现其具有促进肿瘤生成、转移的作用。本文就其在乳腺癌细胞中发挥作用的潜在作用机制,以及其未来临床应用可能,如作为肿瘤标志物用于早期乳腺癌诊断,评估病人化学药物治疗(以下简称化疗)敏感性,作为辅助化疗药物增强化疗敏感性药物等方面进行综述。
[Abstract]:MicroRNAs (microRNAs) are a class of highly conserved non-coding single-stranded RNAs that silencing target gene expression at post-transcriptional level by specifically binding to the 3'noncoding region of the target gene mRNA. Some studies have shown that the expression of miR-181a is closely related to tumor and plays an important role in tumor formation, invasion and metastasis. There are still many controversies about the role of miR-181a in breast cancer. Some studies have shown that miR-181a has the role of tumor suppressor gene. Other studies have found that it promotes tumorigenesis and metastasis. In this review, the potential mechanism of its role in breast cancer cells and its possible future clinical applications, such as early breast cancer diagnosis as a tumor marker, and the evaluation of chemotherapeutic sensitivity in patients with breast cancer were reviewed. As adjuvant chemotherapeutic agents, chemosensitivity drugs were reviewed.
【作者单位】：首都医科大学附属北京妇产医院生殖医学科;蒙特利尔大学CHU-saint-Justine医院药理学系研究中心;首都医科大学附属北京妇产医院妇科内分泌科;
【基金】：国家自然科学基金(81671411) 北京市自然科学基金(7162062) 国家外国专家局2017年度北京市引进国外技术、管理人才项目(20171100004) 北京市科技新星计划交叉学科合作项目(Z161100004916045) 北京市卫生系统高层次卫生技术人才(学科带头人)(2014-2-016)~~
【分类号】：R737.9

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