上皮样血管内皮瘤12例临床病理分析

发布时间：2018-06-02 18:02

  本文选题：血管内皮瘤 + 肝　； 参考：《临床与实验病理学杂志》2017年03期

【摘要】：目的 探讨实质脏器上皮样血管内皮瘤(epihelioid hemangioendothelioma,EHE)的临床病理学特征、免疫表型、诊断及鉴别诊断。方法 回顾性分析12例手术切除及粗针穿刺活检诊断为EHE的临床病理学特征及免疫表型,并进行随访。结果男性9例,女性3例,患者年龄30~69岁,平均43.5岁。其中肝脏8例,骨组织3例,肺组织1例。镜检:圆形及卵圆形上皮样细胞为散在单个、巢团状、条索状排列,瘤细胞胞质嗜酸性,可见细胞质内空泡及散在红细胞,间质黏液样变性,有些病例可见散在少数钙化。免疫表型:CD34、CD31、FⅧRAg均呈阳性,多数病例均带瘤存活,1例患者术后半年复发,1例患者随访100个月后死亡,3例患者失访。结论 EHE属于少见的血管源性低度恶性肿瘤,尤其发生于实质脏器者,临床及影像学特征无特异性,确诊需结合组织病理学、免疫表型或分子生物学检查WWTR1-CAMTA1融合基因。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of epihelioid hemangioendothelioma (EHEs) in parenchymal organs. Methods the clinicopathological features and immunophenotype of 12 cases of EHE diagnosed by surgical resection and coarse needle biopsy were retrospectively analyzed and followed up. Results there were 9 males and 3 females with an average age of 43.5 years (30 ~ 69 years). There were 8 cases of liver, 3 cases of bone tissue and 1 case of lung tissue. Microscopic examination: round and oval epithelioid cells were scattered in a single, nesting, striped arrangement, tumor cell cytoplasm eosinophilic, cytosolic vacuoles and scattered red blood cells, interstitial myxoid degeneration, some cases scattered in a few calcification. The immunophenotype of CD34, CD31 and F 鈪，

本文编号：1969681