外周T细胞淋巴瘤26例疗效及预后因素分析

发布时间：2018-06-02 18:38

本文选题：淋巴瘤 + T细胞　；参考：《中国实用内科杂志》2017年02期

【摘要】：目的研究外周T细胞淋巴瘤(peripheral T-cell lymphoma,PTCL)的疗效和预后因素。方法回顾性分析2010年1月至2013年12月中国医科大学附属盛京医院诊治的26例PTCL患者的临床资料,探讨与疗效及预后相关的因素。结果经治疗后,2例(7.7%)完全缓解(CR),8例(30.8%)部分缓解(PR),7例(26.9%)疾病稳定(SD),9例(34.6%)疾病进展(PD),总有效率(CR+PR,ORR)为38.5%。患者的骨髓受累和CA125升高同患者的近期疗效相关。截至随访日期,死亡17例。中位生存时间为28个月,1年、2年、3年的生存率分别为69.2%、56.7%、41.4%。单因素分析显示,Ann Arbor分期、国际预后指数(IPI)评分、骨髓侵犯、美国东部肿瘤协作组(ECOG)评分、CA125水平、血红蛋白(Hb)110 g/L、血小板计数(PLT)135×109/L、白蛋白35 g/L、治疗后ORR与生存率相关(均P0.05)。多因素分析显示,骨髓侵犯(HR 0.007)、ECOG(HR 0.004)、ORR(HR 0.020)是PTCL患者独立预后因素。结论 PTCL患者预后差,ORR低,骨髓受累和CA125升高同患者的近期疗效相关,Ann Arbor分期、IPI评分、骨髓侵犯、ECOG评分、CA125水平、Hb110 g/L、PLT135×109/L、白蛋白35 g/L、治疗后ORR与生存率相关,骨髓侵犯、ECOG、ORR是PTCL患者独立预后因素。
[Abstract]:Objective to study the efficacy and prognostic factors of peripheral T-cell lymphoma (PTCLs). Methods the clinical data of 26 patients with PTCL treated in Shengjing Hospital affiliated to China Medical University from January 2010 to December 2013 were analyzed retrospectively. Results after treatment, 2 cases (7.7%) were completely relieved (30.8%) and 7 cases (26.9%) were partially relieved.) the disease was stable in 9 cases (34.6%). The total effective rate was 38.5% (CR / PRORR). Bone marrow involvement and increased CA125 were associated with short-term outcomes. As of the follow-up date, 17 cases died. The median survival time was 28 months, 1 year, 2 years, 3 years survival rate was 69.2%, 56.7% and 41.4%, respectively. Univariate analysis showed that Ann Arbor stage, international prognostic index (IPI) score, bone marrow invasion, CA125 level of Ecog group, 110g / L HB, PLT 135 脳 10 9 / L, albumin 35g / L, ORR after treatment were correlated with survival rate (all P 0.05). Multivariate analysis showed that bone marrow invasion (HR 0.007) was an independent prognostic factor in patients with PTCL. Conclusion the prognosis of patients with PTCL is poor, the bone marrow involvement and the increase of CA125 are associated with the short-term curative effect of the patients. The scores of Arbor stage and CA125 of bone marrow invasion are correlated with the levels of HB 110g / L PLT 135 脳 10 9 / L, albumin 35 g / L. ORR is associated with survival rate after treatment. Bone marrow invasion of ECOG orr is an independent prognostic factor in patients with PTCL.
【作者单位】：中国医科大学附属盛京医院第二血液内科;
【基金】：辽宁省科技厅项目(2008225010-13)
【分类号】：R733.1

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