Coronin 1c与肿瘤侵袭和转移相关性研究进展

发布时间：2018-06-03 09:50

本文选题：Coronin + c　；参考：《中华肿瘤防治杂志》2017年12期

【摘要】：目的冠蛋白(Coronins)家族通过调控肌动蛋白生物网络,参与细胞运动等生物活动。本研究介绍Coronins的基本情况,重点探究家族成员Coronin 1c参与侵袭和转移的机制,总结其在肿瘤中的研究进展。方法应用检索Pubmed及CNKI期刊全文数据库检索系统,以"Coronin,冠蛋白"等为关键词,检索2016-11以前的相关文献,共检索到英文文献362条,中文文献24条。纳入标准:(1)冠蛋白的结构,机制及临床作用等;(2)Coronin 1c的相关研究进展。剔除标准:(1)除Coronin 1c之外的其他冠蛋白的相关研究;(2)Coronin 1c非肿瘤的相关研究。符合纳入标准的中文文献12条,英文文献79条,根据剔除标准剔除中文文献12条,英文文献63条,最后纳入分析26篇文献。结果 Coronin 1c通过与Rac1和F-actin发生反应,作用于细胞骨架及其调节因子,调节细胞活动,从而影响肿瘤的侵袭和转移。结论虽然Coronin 1c已在医学领域有了广泛研究,但其对肿瘤领域,尤其是肿瘤的侵袭和转移方面还存在很大的研究空间,需要进一步研究其临床相关性。
[Abstract]:Objective to regulate actin biological network and participate in cell movement and other biological activities. In this study, the basic situation of Coronins was introduced, and the mechanism of family member Coronin 1c involved in invasion and metastasis was investigated, and the research progress of Coronin 1c in tumor was summarized. Methods the Pubmed and CNKI full-text database retrieval system was used to search the related literatures before 2016-11 with "Coronin, Crown protein" as the key words. A total of 362 articles in English and 24 articles in Chinese were retrieved. The structure, mechanism and clinical effect of corononin 1c were included in the study of Coronin 1c. A study on Coronin 1c other than Coronin 1c According to the inclusion criteria, 12 articles of Chinese literature, 79 articles of English literature, 12 articles of Chinese literature and 63 articles of English literature were excluded according to the exclusion criteria. At last, 26 articles were included in the analysis. Results Coronin 1c acted on the cytoskeleton and its regulatory factors by reacting with Rac1 and F-actin, and regulated cell activity, thus affecting the invasion and metastasis of tumor. Conclusion although Coronin 1c has been widely studied in the medical field, there is still a lot of room for research in the field of tumor, especially the invasion and metastasis of tumor, so it is necessary to further study the clinical relevance of Coronin 1c.
【作者单位】：山东大学附属山东省肿瘤医院放疗六科;
【基金】：国家自然科学基金(81530060) 山东省自然科学基金(ZR2015QZ09);山东省自然科学基金(ZR2014YL034)
【分类号】：R73-37

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