乳腺浸润性导管癌组织中Pin1、CyclinD1蛋白表达变化及意义

发布时间：2018-06-07 12:21

本文选题：乳腺浸润性导管癌 + Pin蛋白　；参考：《山东医药》2017年09期

【摘要】：目的观察Pin1和CyclinD1蛋白在乳腺浸润性导管癌组织中的表达并探讨其临床意义。方法采用免疫组化法检测108例乳腺浸润性导管癌和30例正常乳腺组织石蜡切片中Pin1和CyclinD1蛋白表达,分析二者表达与乳腺癌患者临床病理特征的关系。结果 Pinl蛋白在正常乳腺组织中不表达,在乳腺癌组织中阳性表达定位于细胞核,微弱表达时胞核少许轻微着色,过表达时胞核和胞质均着色。Pinl蛋白在55.6%(60/108)乳腺浸润性导管癌患者癌组织中呈阳性或强阳性表达。Pin1蛋白表达与患者组织学分级、淋巴结转移有关(P均0.05),而与年龄、肿瘤大小、临床分期无关(P均0.05)。CyclinD1蛋白在正常乳腺组织中不表达。CyclinD1蛋白在乳腺癌组织中阳性表达定位于细胞核,65例表达阳性,阳性表达率为60.2%。CyclinD1蛋白表达与淋巴结转移有关(P0.05),而与年龄、肿瘤大小、组织学分级、临床分期无关(P均0.05)。在浸润性导管癌组织中Pin1与CyclinD1蛋白表达呈正相关(r=0.224,P0.05)。结论 Pin1和CyclinD1蛋白在浸润性乳腺癌组织中呈高表达;二者可能在乳腺浸润性导管癌侵袭和转移中发挥作用。
[Abstract]:Objective to investigate the expression of Pin1 and CyclinD1 protein in breast invasive ductal carcinoma and its clinical significance. Methods the expression of Pin1 and CyclinD1 in paraffin sections of 108 cases of breast invasive ductal carcinoma and 30 cases of normal breast tissue were detected by immunohistochemical method. The relationship between the expression of Pin1 and CyclinD1 and the clinicopathological features of breast cancer was analyzed. Results there was no expression of Pinl protein in normal breast tissues, but the positive expression was located in the nucleus in breast cancer tissues. In breast invasive ductal carcinoma, the positive or strong positive expression of Pin 1 protein was correlated with histological grade, lymph node metastasis (P < 0.05), age and tumor size. The positive expression of cyclin D1 protein in breast cancer tissues was found in 65 cases of breast cancer. The positive rate of expression of 60.2%.CyclinD1 protein was related to lymph node metastasis (P 0.05), but to age. Tumor size, histological grade, clinical stage were not significant (P < 0.05). There was a positive correlation between the expression of Pin1 and CyclinD1 protein in invasive ductal carcinoma. Conclusion Pin1 and CyclinD1 proteins are highly expressed in invasive breast cancer and may play an important role in invasion and metastasis of invasive ductal carcinoma of breast.
【作者单位】：惠州市第一人民医院;
【基金】：惠州市科技局研究项目(0039107150321045)
【分类号】：R737.9

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