自拟养金愈癌汤改善NSCLC患者血清CEA及免疫功能的临床观察

发布时间：2018-06-09 00:26

本文选题：非小细胞肺癌 + 血清CEA　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:采用随机对照试验,观察自拟养金愈癌汤对非小细胞肺癌(NSCLC)气阴两虚型患者血清CEA及免疫功能等的影响,从而评价其临床疗效及用药安全性,为该方剂的临床应用提供可靠依据。方法:本研究共收录符合纳入标准的患者60例,随机分为两组,治疗组30例采用自拟养金愈癌汤+TP化疗方案、对照组30例采用单纯TP化疗方案,共给药2个疗程,每疗程21天。试验结束后比较两组患者用药前后血清CEA、中医证候积分、KPS评分及免疫指标CD3+,CD4+,CD4+/CD8+的改善情况,以及用药后的血常规和肝肾功情况。结果:1.治疗组患者血清CEA水平下降更明显,与对照组比较有差异(p0.05)。2.治疗组患者主要中医症状及体力状况改善更明显,与对照组比较有差异(p0.05)。3.治疗组患者免疫指标CD3+,CD4+,CD4+/CD8+优于对照组(p0.05)。4.治疗组的白细胞、血小板、血红蛋白水平优于对照组(p0.05),而谷丙转氨酶、谷草转氨酶、肌酐、尿素氮水平与对照组无显著差异(p0.05)。结论:1.自拟养金愈癌汤联合TP化疗能够降低非小细胞肺癌患者血清CEA水平。2.自拟养金愈癌汤联合TP化疗能够显著改善非小细胞肺癌患者主要临床症状和体力状况,从而提高患者生存质量。3.自拟养金愈癌汤能一定程度上改善非小细胞肺癌患者化疗后的免疫抑制状态,并对血象和肝肾功无不良影响。
[Abstract]:Objective: To observe the effect of self-made jinjinyu cancer Decoction on serum CEA and immune function of patients with Qi and yin deficiency of non small cell lung cancer (NSCLC) by randomized controlled trial, so as to evaluate the clinical efficacy and safety of drugs, and to provide reliable basis for the clinical application of this prescription. Methods: a total of 60 patients were included in this study. The machine was divided into two groups, and 30 cases in the treatment group were treated with the +TP chemotherapy regimen of self-made Jinyu Yin cancer soup, and 30 cases in the control group were treated with TP chemotherapy alone, and the 2 courses were given for 21 days each. After the trial, the serum CEA, TCM Syndrome score, KPS score and the immune index CD3+, CD4+, CD4+/CD8+, and the improvement of the CD4+/CD8+ were compared. Results of blood routine and liver and kidney work in the 1. treatment group, the decrease of serum CEA level was more obvious, compared with the control group (P0.05) the improvement of the main symptoms and physical conditions of the main Chinese medicine in the.2. treatment group was more obvious, and there was a difference between the control group and the control group (P0.05) the immune index of the patients in the.3. group was CD3+, CD4+, CD4+/CD8+ was superior to the control group (P0.05).4. treatment. The white blood cells, platelets and hemoglobin levels in the treatment group were superior to those of the control group (P0.05), while the level of alanine aminotransferase, cereal transaminase, creatinine and urea nitrogen was not significantly different from that of the control group (P0.05). Conclusion: 1. the self drawn up gold Yin Yin cancer soup combined with TP chemotherapy can reduce the serum CEA level of non small cell lung cancer patients with.2. self-made gold Yu cancer soup combined with TP chemotherapy. The main clinical symptoms and physical conditions of patients with non-small cell lung cancer can be significantly improved, thus improving the quality of life of the patients with.3. self-made Jinyu cancer soup can improve the immunosuppressive state of patients with non-small cell lung cancer after chemotherapy, and have no adverse effects on Hemogram and liver and kidney work.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2

【参考文献】