痰热清注射液对合并慢性阻塞性肺疾病肺癌患者围术期炎症因子的影响

发布时间：2018-06-09 00:28

本文选题：痰热清注射液 + 合并慢性阻塞性肺疾病肺癌　；参考：《中国老年学杂志》2017年24期

【摘要】：目的探讨痰热清能否减轻合并慢性阻塞性肺疾病(COPD)肺癌患者术后炎症反应和肺损伤的程度。方法选择39例合并COPD肺癌患者(痰热瘀肺型)随机分为被试组18例和对照组21例。所有患者行胸腔镜辅助下小切口手术。对照组用西医常规治疗,被试组加用痰热清注射液。在术前1 d(T_1)、术后第1天(T_2)、第3天(T_3)、第7天(T_4)采集血清标本,测定两组血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-8和IL-10浓度。结果在T_1、T_2时间点,两组TNF-α、IL-6、IL-8和IL-10水平无显著差异(P0.05);在T_3时间点,被试组TNF-α、IL-6和IL-8水平明显低于对照组(P0.05),IL-10水平明显高于对照组(P0.05);在T_4时间点,被试组TNF-α、IL-6和IL-8水平明显低于对照组(P0.05),两组T_3、T_4时间点TNF-α、IL-6、IL-8水平均较T_2时间点显著降低(P0.05),T_2、T_3时间点IL-10逐渐上升,均明显高于T1时间点(P0.05)。结论痰热清注射液能减少合并COPD肺癌围术期间炎症因子的释放,增加抗炎症因子生成,从而减轻炎症反应程度,减轻肺脏损伤,保护肺功能。
[Abstract]:Objective to investigate whether Tanreqing can alleviate the postoperative inflammatory reaction and lung injury in patients with chronic obstructive pulmonary disease (COPD). Methods 39 patients with COPD lung cancer (phlegm heat stasis lung type) were randomly divided into two groups: the control group (n = 21) and the control group (n = 18). All patients underwent thoracoscopic assisted small incision surgery. The control group was treated with routine western medicine, and the test group was treated with Tanreqing injection. Serum levels of TNF- 伪, IL-IL-6, IL-8 and IL-10 were measured on the first day before operation, on the first day after operation, on the third day after operation, on the seventh day, and on the seventh day, the serum samples were collected and the levels of TNF- 伪, IL-8 and IL-10 were measured. Results there was no significant difference in the levels of IL-8 and IL-10 between the two groups at the time point of T _ 1 / T _ 2. At the time point of T3, the levels of TNF- 伪 IL-6 and IL-8 in the subjects group were significantly lower than those in the control group (P 0.05), and the levels of IL-10 in the control group were significantly higher than those in the control group (P 0.05), and at the T4 time point, the levels of TNF- 伪, IL-6 and IL-8 were significantly higher than those in the control group. The levels of TNF- 伪 IL-6 and IL-8 in the subjects group were significantly lower than those in the control group (P 0.05), and the levels of TNF- 伪 IL-6 and IL-8 in the two groups were significantly lower than those in the T _ 2 / T _ 2 group, which were significantly higher than those in the T _ 1 / T _ 1 group. Conclusion Tanreqing injection can reduce the release of inflammatory factors and increase the production of anti-inflammatory factors during perioperative period of lung cancer with COPD, so as to reduce the degree of inflammatory reaction, reduce lung injury and protect lung function.
【作者单位】：江西中医药大学附属医院;南昌市中西医结合医院;
【基金】：江西省卫生计生委中医药科研计划(No.2013B033)
【分类号】：R563.9;R734.2

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