铜绿假单胞菌注射液在胃癌治疗中的临床研究

发布时间：2018-06-09 06:55

本文选题：铜绿假单胞菌注射液 + 胃癌　；参考：《兰州大学》2017年硕士论文

【摘要】：目的:探究进展期胃癌患者术中腹腔喷洒铜绿假单胞菌注射液对患者术后免疫力的影响,并评估其不良反应及安全性。方法:选取2014年1月至2016年1月在兰州大学第二医院普外科诊断明确且手术治疗的胃癌患者61例,可评定为T3、T4期。分为实验组(PA-MSHA)和对照组。其中实验组:31例,行胃癌D2根治术,关腹前腹腔喷洒铜绿假单胞菌注射液10ml;对照组:30例,行胃癌D2根治术,术中不使用铜绿假单胞菌注射液。两组其余治疗相同。收集术后第7天两组免疫学指标,血象及肝肾功能,两组对比并分别与术前对比;两组术后一月的肿瘤标记物检测,两组对比并分别与术前对比;汇总术后7日内的总腹腔引流量;两组患者术后肛门开始排气的时间。汇总患者从术后第1天至第7日内的不良反应。结果:实验组术后第7日的免疫学指标检测,其CD3、CD4细胞计数较术前相比是升高的,而CD8细胞计数较术前相比是下降的,具有统计学意义(P㩳0.05);与对照组相比,CD3、CD4及NK细胞计数均升高,CD8细胞计数下降,均有统计学意义(P㩳0.05),其中CD4细胞计数与对照组相比明显升高,具有明显统计学意义(P㩳0.01)。两组术后第7日的血象及肝肾功能指标比较均无统计学差异(P0.05)。两组术后1月肿瘤标记物水平相比无统计学差异(P0.05)。实验组术后7日内的总腹腔引流量低于对照组,有统计学意义(P㩳0.05)。两组术后肛门开始排气时间相比无统计学差异(P0.05)。术后实验组7日内的未出现明显不良反应,安全性较好。结论:进展期胃癌患者术中腹腔喷洒铜绿假单胞菌注射液可以解除或缓解患者免疫受抑制状态,提高自身免疫力,促进术后病情恢复,同时不良反应少,安全性较好。
[Abstract]:Aim: to investigate the effect of intraoperative injection of Pseudomonas aeruginosa on postoperative immunity of patients with advanced gastric cancer and evaluate its adverse reactions and safety. Methods: from January 2014 to January 2016, 61 cases of gastric cancer with definite diagnosis and surgical treatment were selected in the second Hospital of Lanzhou University. The rats were divided into two groups: experimental group (PA-MSHA) and control group. In the experimental group, 31 cases were treated with D2 radical gastrectomy, 10 ml Pseudomonas aeruginosa injection was sprayed intraperitoneally before abdominal closure, and 30 cases in the control group were treated with D2 radical gastrectomy without Pseudomonas aeruginosa injection. The other treatments in both groups were the same. On the 7th day after operation, the immunological indexes, blood picture and liver and kidney function in the two groups were collected and compared with those before operation, the tumor markers were detected in the first month after operation in both groups, and compared with those before operation. Total abdominal drainage was collected within 7 days after operation. Summarize the adverse reactions of the patients from the first day to the seventh day after operation. Results: on the 7th day after operation, the CD4 cell count of CD3 was higher and the CD8 cell count was lower in the experimental group than that before operation. Compared with the control group, the CD4 and NK cell counts of CD _ 3O _ 4 increased and CD _ 8 cell count decreased, and the CD4 cell count was significantly higher than that of the control group (P < 0.05), and the count of CD _ 4 cells was significantly higher than that of the control group (P < 0.01). There was no significant difference in blood picture and liver and kidney function between the two groups on the 7th day after operation (P 0.05). There was no significant difference in tumor marker level between the two groups at 1 month after operation (P 0.05). The total abdominal drainage volume in the experimental group was significantly lower than that in the control group within 7 days after operation. There was no significant difference between the two groups in the onset time of anal exhaust (P 0.05). There was no obvious adverse reaction within 7 days after operation in the experimental group, and the safety was good. Conclusion: spraying pseudomonas aeruginosa injection intraperitoneally in patients with advanced gastric cancer can relieve or relieve the immunosuppressive state of the patients, improve their own immunity, promote the recovery of the disease after operation, and have less adverse reactions and better safety.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.2

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