芪络汤对大肠癌手术化疗后脾虚湿热证患者生活质量的影响

发布时间：2018-06-11 22:57

  本文选题：芪络汤 + 大肠癌　； 参考：《福建中医药大学》2016年硕士论文

【摘要】：目的：观察芪络汤对大肠癌手术化疗后脾虚湿热证患者生活质量等的影响及其安全性评估。方法：本研究采用随机平行对照试验法,将64例符合纳入标准的大肠癌手术化疗后脾虚湿热证的患者随机分为治疗组32例和对照组32例。治疗组予口服芪络汤,对照组予注射胸腺五肽。3个月后,比较两组患者的生活质量、体重、中医证侯积分、细胞免疫功能、肿瘤标志物等方面作为疗效评价,记录不良反应,并观察血常规和心肝肾功结果作为安全性评价,并对数据进行统计分析。结果：(1)研究总纳入64例,脱失2例,实际完成62例,总脱失率3.1%。(2)生活质量：治疗结束后,治疗组生活质量提高16例,稳定15例,降低0例,对照组生活质量提高7例,稳定19例,降低5例,两组比较差异有统计学意义(P＜0.05)。(3)体重变化：治疗结束后,治疗组体重升高11例,稳定17例,降低3例,对照组体重升高5例,稳定18例,降低8例,两组差异有统计学意义(P＜0.05)。(4)中医证侯疗效：治疗后,治疗组的中医证候积分较对照组显著降低(P≥0.05),各单项中医证候中,治疗组神疲乏力、气短懒言、口干口苦、肢体困重、食欲不振、便溏或结等证候的改善明显优于对照组(P＜0.05)。(5)血清肿瘤标志物比较：两组患者血清CEA、CA199水平治疗后均无明显变化(P＞.05)。(6)免疫指标：治疗组和对照组治疗后CD3+、CD4+、CD4+/CD8+、NK细胞等免疫指标较治疗前均明显升高(P＜O.05)；两组CD8+均显著下降(P＜0.05)；而治疗后两组各项免疫指标的变化比较无显著差异(P＜0.05)。(7)安全性评估：治疗组新发轻度恶心1例,未作处理自行缓解,两组对血常规和心肝肾功能均未造成不良影响。结论：芪络汤能明显改善大肠癌手术化疗后脾虚湿热证患者生活质量和中医证侯积分;芪络汤对患者的体重下降有保护作用；芪络汤能明显提高患者细胞免疫水平；临床应用安全有效。
[Abstract]:Objective: to observe the effect of Qiluo decoction on quality of life of patients with spleen deficiency dampness heat syndrome after operation chemotherapy for colorectal cancer. Methods: in this study, 64 patients with spleen deficiency dampness and heat syndrome were randomly divided into treatment group (n = 32) and control group (n = 32). The treatment group was treated with Qiluo decoction and the control group was injected with thymic pentapeptide. After 3 months, the quality of life, weight, TCM syndromes score, cellular immune function, tumor markers and other aspects of the patients in the two groups were compared as therapeutic evaluation, and adverse reactions were recorded. The blood routine and the results of heart, liver and kidney were observed as safety evaluation, and the data were statistically analyzed. Results in the study, 64 cases were included, 2 cases were lost, 62 cases were actually completed, and the total loss rate was 3.1%. 2) the quality of life in the treatment group was improved in 16 cases, stable in 15 cases, decreased in 0 cases after treatment. In the control group, the quality of life was improved in 7 cases. There were 19 stable cases, 5 cases decreased. The difference between the two groups was statistically significant (P < 0.05). The weight of the treatment group increased in 11 cases, stabilized in 17 cases, decreased in 3 cases, and increased in 5 cases, stable in 18 cases and decreased in 8 cases in the control group. The difference between the two groups was statistically significant (P < 0.05).) the curative effect of TCM syndrome: after treatment, the score of TCM syndrome in the treatment group was significantly lower than that in the control group (P 鈮，

本文编号：2007010