蛋白亚细胞定位与肿瘤关系的研究进展

发布时间：2018-06-12 13:24

本文选题：肿瘤 + 蛋白质加工　；参考：《肿瘤》2017年06期

【摘要】：肿瘤相关蛋白亚细胞定位的改变可影响其蛋白结构和生物学功能,与肿瘤的发生、发展及预后密切相关。异常的磷酸化、乙酰化和泛素化修饰可影响肿瘤相关蛋白的亚细胞定位,进而改变下游靶基因表达及相关细胞信号通路,这是诱导肿瘤发生的重要因素。作用于蛋白翻译后修饰的抗癌药物可逆转肿瘤相关蛋白的异常亚细胞定位,进而抑制肿瘤细胞迁移,并促进细胞凋亡。本文以p53、叉头框蛋白O1(forkhead box protein O1,FOXO1)和p27等分子为例,总结了磷酸化、乙酰化和泛素化修饰对这些蛋白亚细胞定位的影响,以及目前影响蛋白亚细胞定位的抗癌药物的作用机制,并讨论了蛋白亚细胞定位对临床恶性肿瘤诊断、预后判断和药物作用效果预测具有的重要意义。
[Abstract]:The changes of subcellular localization of tumor-associated proteins may affect their protein structure and biological functions, and are closely related to the occurrence, development and prognosis of tumors. Abnormal phosphorylation, acetylation and Ubiquitin modification can affect the subcellular localization of tumor-associated proteins, and then change the downstream target gene expression and related cell signaling pathway, which is an important factor to induce tumorigenesis. The antitumor drugs modified after protein translation can reverse the abnormal subcellular localization of tumor-associated proteins and thus inhibit the migration of tumor cells and promote cell apoptosis. In this paper, the effects of phosphorylation, acetylation and ubiquitin modification on the subcellular localization of p53, forkhead box protein O1FXO1) and p27 were summarized, as well as the mechanisms of anticancer drugs affecting the localization of protein subcells. The significance of protein subcellular localization in clinical malignant tumor diagnosis, prognosis and prediction of drug effect was discussed.
【作者单位】：浙江省医学科学院分子医学中心;
【基金】：浙江省科学技术协同创新项目(编号:2014F50014) 浙江省科技研究项目(编号:2016F10009) 浙江省医学科学院青年基金项目(编号:2015Y001) 浙江省医药卫生科研基金项目(编号:2017KY308) 国家自然科学基金资助项目(编号:81301782)~~
【分类号】：R730.2

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