黑色素瘤缺乏因子2在肿瘤发生发展中的研究进展

发布时间：2018-06-13 23:36

本文选题：黑色素瘤缺乏因子 + 固有免疫　；参考：《医学研究生学报》2017年05期

【摘要】：黑色素瘤缺乏因子2(AIM2)是一种位于细胞质的蛋白质,能够识别并结合细胞质双链DNA(dsDNA)进而激活含半胱氨酸的天冬氨酸蛋白水解酶-1(Caspase-1),促进IL-1β和IL-18成熟释放,或诱导细胞焦亡。AIM2属于固有免疫系统,是保护机体不受外来微生物侵害的第一道防线,识别病原微生物之后,激活宿主信号引起反应,从而启动固有免疫和获得性免疫应答。研究还表明,AIM2在肿瘤的发生发展中扮演重要角色,AIM2在前列腺癌、结直肠癌、乳腺癌、鼻咽癌、口腔鳞状细胞癌、非小细胞肺癌等恶性肿瘤中的表达亦存在异常,并且在不同肿瘤的进展过程中发挥不同作用。文章就AIM2在固有免疫及肿瘤发生发展等方面的研究进展进行综述。
[Abstract]:Melanoma deficiency factor 2 (AIM2) is a cytoplasmic protein that recognizes and binds to the cytoplasmic double stranded DNA (dsDNA) and activates the cysteine-containing aspartate protein hydrolase -1Caspase-1, which promotes the mature release of IL-1 尾 and IL-18. AIM2 belongs to the innate immune system and is the first line of defense to protect the body from the invasion of foreign microorganisms. After the pathogen is identified, the host signal is activated and the response is induced, thus initiating the innate and acquired immune responses. The results also show that AIM2 plays an important role in the development of tumors. The expression of AIM2 is also abnormal in prostate cancer, colorectal cancer, breast cancer, nasopharyngeal carcinoma, oral squamous cell carcinoma, non-small cell lung cancer and other malignant tumors. And play different roles in the progression of different tumors. This article reviews the progress of AIM2 in innate immunity and tumorigenesis and development.
【作者单位】：苏州大学附属第一医院普外科;
【基金】：国家自然科学基金项目(81672348) 江苏省“六大高峰人才”项目(2015-WSW-014) 江苏省卫生高层次人才“六个一工程”项目(LGY2016031) 江苏省“科教强卫工程”青年医学人才项目(QNRC2016735)
【分类号】：R730.2

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