高危型HPV感染对宫颈病变组织Th1Th2相关指标表达的影响研究

发布时间：2018-06-14 22:18

本文选题：高危型HPV感染 + 宫颈病变组织　；参考：《中华医院感染学杂志》2017年03期

【摘要】：目的研究与观察高危型HPV感染对宫颈病变组织Th1Th2相关指标表达的影响,以了解高危型HPV感染对该类患者免疫状态的影响。方法选取2015年3月-2016年4月65例高危型HPV感染患者为A组,65例低危型HPV感染患者为B组,65名健康同龄妇女为C组,检测及比较3组受试者的宫颈组织Th1Th2相关指标表达情况,然后比较A组不同病毒载量及分型患者的Th1Th2相关指标表达情况。结果 A组的组织IFN-γ阳性表达率为13.85%,明显低于B组21.54%及C组38.46%,B组则低于C组;A组的组织IL-4、IL-10、IL-13及TNF-α的阳性表达率为36.92%、41.54%、40.00%及49.23%,均高于B组23.08%、26.15%、23.08%、27.69%及C组1.54%、3.08%、1.54%、4.62%,B组则高于C组;A组不同病毒载量患者的阳性表达率也存在明显差异(P0.05),但不同分型患者的阳性表达率无明显差异。结论高危型HPV感染患者宫颈病变组织Th1Th2相关指标表达较高,且病毒载量对其表达水平也有较大影响,因此应重视对高危型HPV感染患者上述指标的监测与改善。
[Abstract]:Objective to investigate and observe the effect of high risk HPV infection on the expression of Th1Th2 related indexes in cervical lesions in order to understand the effect of high risk HPV infection on the immune status of this type of patients. Methods in March 2015 -2016 year, 65 cases of high-risk HPV infected patients were selected as A group, 65 cases of low risk HPV infected patients were B group, 65 healthy women of the same age were group C, The expression of Th1Th2 related indexes in the cervical tissue of the 3 groups was detected and compared, and then the expression of Th1Th2 related indexes in the A group was compared with those of the A group. The positive expression rate of IFN- gamma in the group A was significantly lower than that in the group B 21.54% and the C group, and the B group was lower than the group C, and the A group was IL-4, IL-10, etc. The positive expression rate of alpha was 36.92%, 41.54%, 40% and 49.23%, which were higher than that of group B 23.08%, 26.15%, 23.08%, 27.69% and C 1.54%, 3.08%, 1.54%, 4.62%, and group B were higher than that of group C, and the positive rate of different viral load patients in A group was also significantly different (P0.05), but there was no significant difference in the positive rate of different types of patients. Conclusion high risk HPV infection was found. The expression of Th1Th2 related indexes in cervical lesions is higher, and the viral load has a great influence on the expression level. Therefore, attention should be paid to the monitoring and improvement of the above indexes in high-risk patients with HPV infection.
【作者单位】：郑州大学附属郑州中心医院妇产科;郑州大学第三附属医院妇科;
【基金】：河南省卫生计生委科技攻关项目(201303090)
【分类号】：R737.33

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