大肝癌根治术前先行射频消融保守治疗的可行性

发布时间：2018-06-14 23:26

本文选题：大肝癌 + 射频消融　；参考：《实用医学杂志》2017年17期

【摘要】：目的探讨大肝癌患者根治术前先行CT引导下的射频消融保守治疗的可行性。方法以近期我院肿瘤内科行射频消融保守治疗和大肝癌根治术的继发性大肝癌患者作为射频消融组(n=27)和手术治疗组(n=33)。观察两组患者治疗后肝功能、免疫细胞、术后并发症、住院时间、无复发3年生存率等临床指标差异。结果治疗后7 d,射频消融组患者肝功能(ALT、AST、ALB、TB)和免疫细胞亚群(CD3~+T、CD4~+T、CD8~+T、CD4~+/CD8~+、NK、B、Treg)均高于手术治疗组(P0.05)。射频消融组患者住院时间、并发症发生率明显低于手术治疗组(P0.05)。射频消融组无复发3年生存率与手术治疗组相比,差异无统计学意义(P0.05)。结论继发性大肝癌根治术前先行射频消融保守治疗方案,虽然并不能有效提升患者无复发生存率,但患者术后恢复较快,并发症发生较少,且可有效保护患者肝功能及免疫功能,不失为一种可行的大肝癌根治术前保守治疗方案。
[Abstract]:Objective to investigate the feasibility of conservative radiofrequency ablation (RFCA) in patients with large hepatocellular carcinoma (HCC) before radical resection. Methods the patients with secondary large liver cancer undergoing radiofrequency ablation conservative therapy and radical resection of large hepatocellular carcinoma were used as radiofrequency ablation group (n = 27) and surgical treatment group (n = 33). The difference of liver function, immune cell, postoperative complications, hospitalization time and 3 year survival rate after treatment between the two groups were observed. Results on the 7th day after treatment, the liver function of patients with radiofrequency ablation (RFA) and the immune cell subsets CD3 ~ TU, CD8 ~ TU CD4 ~ / CD8 ~ / NKBU Treg) in radiofrequency ablation group were significantly higher than those in operation group (P 0.05). The incidence of complications in radiofrequency ablation group was significantly lower than that in operation group (P 0.05). The 3-year recurrence-free survival rate in radiofrequency ablation group was not significantly different from that in surgical treatment group (P 0. 05). Conclusion the conservative treatment of radiofrequency ablation before radical resection of secondary large hepatocellular carcinoma can not effectively improve the survival rate of patients without recurrence, but the patients recover faster and have fewer complications after operation. It can effectively protect the liver function and immune function of the patients. It is a feasible conservative treatment scheme before radical resection of large liver cancer.
【作者单位】：河北省邢台市人民医院肿瘤内科;河北省邢台市人民医院放射科;
【基金】：邢台市科技计划项目(编号:2015ZC210)
【分类号】：R735.7

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