急诊肿瘤晚期感染患者的病原菌分布及炎性指标变化的意义分析

发布时间：2018-06-24 00:03

本文选题：急诊 + 肿瘤晚期　；参考：《中华医院感染学杂志》2017年23期

【摘要】：目的分析急诊肿瘤晚期感染患者的病原菌分布及炎性指标变化的意义,为提高临床诊断治疗效果提供客观依据。方法选取2015年1月-2016年12月医院急诊收治的89例晚期肿瘤合并感染患者作为研究对象,对患者感染部位进行观察和分析,对患者感染分泌物样本中的病原菌分布及耐药性进行检测和分析,对患者入院时血样本中炎症标志物水平进行检测和比较。结果 89例感染患者共检出94株病原菌,以革兰阴性菌为主,共53株占56.4%;主要革兰阴性菌对环丙沙星、磺胺甲VA唑/甲氧苄啶的耐药率较高,对阿米卡星较为敏感;革兰阴性菌感染患者的血浆降钙素原(PCT)、C-反应蛋白(CRP)、脂多糖(LPS)水平均高于革兰阳性菌感染患者(P0.05)。结论急诊肿瘤晚期合并感染患者的感染部位、病原菌分布及耐药性、炎症指标变化均具有一定的特征,临床医生应给予高度的重视、密切的监测及有效的诊治,以提高感染的诊治效果,改善患者的预后。
[Abstract]:Objective to analyze the significance of the distribution of pathogenic bacteria and the changes of inflammatory indexes in patients with advanced infection of tumor in emergency, and to provide an objective basis for improving the effect of clinical diagnosis and treatment. Methods from January 2015 to December 2016, 89 patients with advanced tumor complicated with infection were selected as study objects, and the site of infection was observed and analyzed. The distribution and drug resistance of pathogenic bacteria in infected secretions were detected and analyzed, and the levels of inflammatory markers in blood samples were detected and compared. Results A total of 94 strains of pathogenic bacteria were detected in 89 infected patients, 53 of them were Gram-negative bacteria (56.4%), the main gram-negative bacteria were resistant to ciprofloxacin, sulfamethazol / trimethoprim, and sensitive to amikacin. The levels of plasma procalcitonin (PCT) C-reactive protein (CRP) and lipopolysaccharide (LPS) in patients with Gram-negative bacteria infection were higher than those in patients with Gram-positive bacteria infection (P0.05). Conclusion the infection site, the distribution of pathogenic bacteria, the resistance of pathogens and the changes of inflammatory indexes in patients with advanced tumor infection in emergency department have some characteristics. The clinicians should pay close attention to the infection, monitor closely and treat effectively. In order to improve the diagnosis and treatment of infection, improve the prognosis of patients.
【作者单位】：山东省医学科学院附属医院急诊科;山东省警官总医院医疗科;
【分类号】：R730.43

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