宫颈细胞学联合高危型HPV检测在子宫颈癌及癌前病变检出中的作用

发布时间：2018-06-24 15:34

  本文选题：宫颈细胞学 + 高危型HPV检测　； 参考：《中国妇产科临床杂志》2017年01期

【摘要】：目的 对宫颈细胞学、高危型HPV和联合检测(细胞学联合高危型HPV检测)3种方法在检出宫颈癌及癌前病变中的作用进行了比较。方法 从2014年1月至2015年12月在北京大学第三医院妇科门诊自愿行机会性筛查的妇女,进行宫颈细胞学检查和高危型HPV检测及阴道镜检查和宫颈活检组织病理学检查。宫颈细胞学采用Surepath和Thinprep液基薄片的方法,高危型HPV检测采用HC2和Cobas 4800检测系统。结果两年间共有3 467例妇女入组进行机会性筛查,年龄24~65岁,宫颈细胞学检出宫颈癌及癌前病变的漏诊率(9.03%)高于高危型HPV检测(2.66%)和联合检测(0.21%),差异有统计学意义(P0.001)。高危型HPV阳性的ASC-US、ASC-H、LSIL、HSIL和AGC经组织病理学检出≥CIN2病变的概率均比HPV阴性者高(P0.05)。结论 联合检测检出宫颈癌及癌前病变的漏诊率低于细胞学和HPV检测,联合检测能为异常筛查结果的管理提供更多指导临床的信息,并有助于提高宫颈腺癌的检出。
[Abstract]:Objective to compare the role of cervical cytology, high risk HPV and combined detection (cytology combined with high risk HPV detection) in the detection of cervical cancer and precancerous lesions. Methods from January 2014 to December 2015, women who volunteered for opportunistic screening in gynecological outpatient clinic of Peking University third Hospital were examined with cervical cytology, high-risk HPV, colposcopy and cervical biopsy histopathology. Cervical cytology was performed by Surepath and Thinprep liquid-based smears, and HC2 and Cobas 4800 were used for high-risk HPV detection. Results A total of 3 467 women were selected for opportunistic screening, aged 24 to 65 years. The missed diagnosis rate of cervical cancer and precancerous lesions detected by cervical cytology (9.03%) was higher than that of high-risk HPV (2.66%) and combined detection (0.21%). The difference was statistically significant (P0.001). The probability of HSIL and AGC detecting 鈮，

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