热疗联合培美曲塞、顺铂治疗中晚期肺腺癌的疗效分析

发布时间：2018-06-26 10:24

本文选题：热疗 + 培美曲塞　；参考：《中国药房》2017年33期

【摘要】：目的:观察热疗联合培美曲塞、顺铂治疗中晚期肺腺癌的疗效和安全性。方法:回顾性分析120例中晚期肺腺癌患者资料,按治疗方案不同分为对照组(60例)和观察组(60例)。对照组患者给予注射用培美曲塞二钠500 mg/m~2,静脉滴注,d1+注射用顺铂75 mg/m~2,静脉滴注,d2~4(分3 d使用)。21 d为1个周期,至少化疗2个周期。观察组患者在对照组化疗的基础上行热疗每月1次,共2~4次。观察两组患者的临床疗效,生活质量改善情况及毒副反应发生情况。结果:两组患者至少接受2个周期治疗。观察组患者总有效率(63.3%)显著高于对照组(36.7%),生活质量改善率(60.0%)显著高于对照组(33.3%),差异均有统计学意义(P0.05)。两组患者Ⅲ~Ⅳ度肝肾功能损害、骨髓抑制、消化道反应发生率比较,差异均无统计学意义(P0.05)。结论:热疗联合培美曲塞、顺铂治疗中晚期肺腺癌的疗效显著,可提高生存质量,且未增加严重毒副反应的发生率。
[Abstract]:Objective: to observe the efficacy and safety of hyperthermia combined with pemetrexide and cisplatin in the treatment of advanced lung adenocarcinoma. Methods: 120 patients with advanced lung adenocarcinoma were retrospectively analyzed and divided into control group (n = 60) and observation group (n = 60). Patients in the control group were given pemetrexed disodium 500 mg / mm-2, cisplatin 75 mg / m-2 for intravenously infused D1, and pemetrexide for 3 days for 21 days, at least 2 cycles of chemotherapy. The patients in the observation group were treated with hyperthermia once a month on the basis of chemotherapy in the control group. To observe the clinical effect, quality of life improvement and side effects of the two groups. Results: two groups of patients received at least 2 cycles of treatment. The total effective rate (63.3%) in the observation group was significantly higher than that in the control group (36.7%), and the improvement rate of quality of life (60.0%) was significantly higher than that in the control group (33.3%), the difference was statistically significant (P0.05). There was no significant difference in the incidence of liver and kidney dysfunction, bone marrow suppression and digestive tract reaction between the two groups (P0.05). Conclusion: hyperthermia combined with pemetrexide is effective in the treatment of middle and advanced lung adenocarcinoma. It can improve the quality of life and does not increase the incidence of severe side effects.
【作者单位】：解放军第150中心医院肿瘤科;
【分类号】：R734.2

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