CA19-9、s-ULBP2、Dkk1联合诊断胰腺癌的价值

发布时间：2018-06-26 10:26

本文选题：胰腺癌 + 糖类抗原　；参考：《实用医学杂志》2017年24期

【摘要】：目的研究CA19-9、s-ULBP2、Dkk1联合诊断胰腺癌的价值及相关性。方法选择2016年1月至2017年5月住院胰腺癌患者56例,同期健康体检健康者45例和良性胰腺病患者33例作为研究对象,比较3组血清CA19-9、Dkk1与s-ULBP2表达及与临床病理参数的关系。分析CA19-9、s-ULBP2、Dkk1及联合检测诊断胰腺癌的诊断效能。结果胰腺癌患者血清CA19-9、s-ULBP2及Dkk1含量明显高于良性胰腺病组及健康对照组(P0.05)。CA19-9、s-ULBP2与TNM分期、组织分化程度有关,且CA19-9与肿瘤部位也有关。联合检测诊断值高于任意指标单独检测。结论 CA19-9、s-ULBP2、Dkk1与胰腺癌关系密切,三者联合检测可提高胰腺癌诊断准确率。
[Abstract]:Objective to study the value and correlation of combined diagnosis of pancreatic cancer with CA19-9 s-ULBP 2 and Dkk 1. Methods from January 2016 to May 2017, 56 patients with pancreatic cancer, 45 healthy controls and 33 patients with benign pancreatic disease were selected. The expression of serum CA19-9 Dkk1 and s-ULBP2 and their relationship with clinicopathological parameters were compared among the three groups. To analyze the diagnostic efficacy of CA19-9-ULBP2Dkk1 and its combined detection in pancreatic cancer. Results the serum levels of CA19-9 + -ULBP2 and Dkk1 in patients with pancreatic cancer were significantly higher than those in benign pancreatic disease group and healthy control group (P0.05). CA19-9s-ULBP2 was related to TNM stage and tissue differentiation, and CA19-9 was also related to tumor location. The diagnostic value of joint detection was higher than that of any index alone. Conclusion CA19-9 and ULBP2Dkk1 are closely related to pancreatic carcinoma, and the combined detection of them can improve the diagnostic accuracy of pancreatic cancer.
【作者单位】：河北北方学院附属第一医院肝胆外科;
【基金】：河北省2017年度医学科学研究重点课题计划(编号:20170819)
【分类号】：R735.9

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