BCL11A在宫颈癌中的表达及其临床意义

发布时间：2018-06-26 20:05

本文选题：BCLA + 宫颈癌　；参考：《重庆医科大学学报》2017年12期

【摘要】：目的:深入研究BCL11A在宫颈癌组织及癌旁正常组织中的表达情况及其与临床病理因素的相关性。方法:收集62例宫颈癌组织及相对应的癌旁正常组织,制作成石蜡切片,并通过免疫组织化学法检测BCL11A蛋白在宫颈癌组织和癌旁正常组织中的表达,并结合患者资料,采用卡方检验分析BCL11A的表达与患者年龄、肿瘤大小、淋巴结受累等临床病理因素之间的关系。结果:(1)免疫组化结果显示,相比癌旁宫颈正常组织,BCL11A在癌组织中表达显著升高,并且具有统计学意义(P0.01)。(2)BCL11A在宫颈癌组织中的表达定位也具有差异性,BCL11A在宫颈癌组织中的表达主要定位于细胞核,而在癌旁正常组织中BCL11A的表达主要定位于细胞质。(3)BCL11A的表达与患者的年龄(P=0.436)、临床分级(P=0.683)、肿瘤大小(P=0.734)以及淋巴结转移数目(P=0.439)无关,但与淋巴结受累情况有关,出现淋巴结转移(N1-3)的患者中BCL11A蛋白的表达水平高于未出现淋巴结转移(N0)的患者(P=0.043)。结论:BCL11A在宫颈癌组织中高表达,在癌旁正常组织中表达较低;BCL11A的表达与宫颈癌患者的淋巴结转移情况相关,即出现淋巴结转移的患者BCL11A的表达较高;在宫颈癌组织中BCL11A的表达主要定位于在细胞核中,而在癌旁正常组织中,BCL11A的表达主要定位于细胞质中。BCL11A可能在宫颈癌的发生发展中起着重要作用。
[Abstract]:Objective: to investigate the expression of BCL11A in cervical carcinoma and adjacent normal tissues and its correlation with clinicopathological factors. Methods: a total of 62 cases of cervical cancer tissues and adjacent normal tissues were collected and made into paraffin sections. The expression of BCL11A protein in cervical cancer tissues and adjacent normal tissues was detected by immunohistochemical method. The correlation of BCL11A expression with age, tumor size, lymph node involvement and other clinicopathological factors was analyzed by chi-square test. Results: (1) Immunohistochemical results showed that the expression of BCL11A in cancer tissues was significantly higher than that in adjacent normal cervical tissues. The expression of BCL11A in cervical carcinoma was also different. The expression of BCL11A in cervical carcinoma was mainly located in the nucleus. The expression of BCL11A in adjacent normal tissues was mainly located in the cytoplasm. (3) the expression of BCL11A was not related to the patient's age (P0. 436), clinical grade (P0. 683), tumor size (P0. 734) and the number of lymph node metastasis (P0. 439), but it was related to the lymph node involvement. The expression of BCL11A protein in patients with lymph node metastasis (N1-3) was significantly higher than that in patients without lymph node metastasis (P0. 043). Conclusion the high expression of BCL11A in cervical carcinoma and the lower expression of BCL11A in adjacent normal tissues are associated with lymph node metastasis of cervical cancer, that is, the expression of BCL11A is higher in patients with lymph node metastasis. The expression of BCL11A in cervical carcinoma is mainly located in the nucleus, while in the adjacent normal tissue, the expression of BCL11A is mainly located in the cytoplasm. BCL11A may play an important role in the occurrence and development of cervical cancer.
【作者单位】：重庆医科大学分子医学与肿瘤研究中心;
【分类号】：R737.33

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