63例胰腺神经内分泌肿瘤的临床特征与预后分析

发布时间：2018-06-26 20:48

本文选题：胰腺神经内分泌肿瘤 + 临床表现　；参考：《中国肿瘤临床》2017年16期

【摘要】：目的:探讨胰腺神经内分泌肿瘤(pancreatic neuroendocrine tumors,PNETs)的发病特点、诊断、治疗及预后的影响因素。方法:回顾性分析2004年8月至2016年8月浙江大学医学院附属邵逸夫医院确诊为PNETs并接受手术治疗的患者63例。收集患者的临床资料,包括年龄、性别、肿瘤功能性、根治性切除等信息,通过单因素、多因素分析的方法求证各因素与预后之间的关系。结果:本研究患者总生存时间(overall survival,OS)为5~127个月,中位生存时间(median overall survival,mOS)为46.6个月。3年及5年生存率分别为88.8%和84.1%。在63例患者中,无功能型占65.1%(41/63),功能型占34.9%(22/63)。单因素分析结果显示淋巴结转移、肝转移、血管侵犯、TNM分期、病理分级以及是否行根治性手术与预后相关(P0.05)。多因素分析结果并未显示其中存在影响PNETs预后的独立因素。结论:PNETs是一类低度恶性的异质性罕见肿瘤,TNM分期和世界卫生组织(WHO)病理分级能积极指导预后,且淋巴结转移、肝转移、血管侵犯情况对预后有影响。患者经积极手术,尤其是根治性手术可获得较好的预后。
[Abstract]:Objective: to investigate the pathogenesis, diagnosis, treatment and prognostic factors of pancreatic neuroendocrine tumors (pancreatic neuroendocrine tumors). Methods: from August 2004 to August 2016, 63 patients with PNETs who were diagnosed as PNETs and received surgical treatment were analyzed retrospectively. The clinical data, including age, sex, tumor function, radical resection and so on, were collected, and the relationship between the factors and prognosis was verified by univariate and multivariate analysis. Results: the total survival time (overall survival OS) and median survival time (median overall survival time) were 5 ~ 127 months and 46.6 months, respectively. The 3-year and 5-year survival rates were 88.8% and 84.1%, respectively. Of 63 patients, 65.1% (41 / 63) were non-functional and 34.9% (22 / 63) were functional. Univariate analysis showed that lymph node metastasis, liver metastasis, vascular invasion TNM stage, pathological grade and whether to perform radical surgery were associated with prognosis (P0.05). Multivariate analysis did not show that there were independent factors affecting the prognosis of PNETs. Conclusion the TNM staging and WHO pathological grading of the low grade malignant heterogeneous rare tumors can positively guide the prognosis, and lymph node metastasis, liver metastasis and vascular invasion may influence the prognosis. Patients with active surgery, especially radical surgery, can obtain a better prognosis.
【作者单位】：浙江大学医学院附属邵逸夫医院普外科;
【基金】：浙江省科技厅重点研发计划项目(编号:2015C03G2010160) 浙江省自然科学基金项目(编号:LY17H160015)资助~~
【分类号】：R735.9

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