FOXF1蛋白在胃癌中的表达及意义

发布时间：2018-07-01 15:29

本文选题：FOXF蛋白 + 胃癌　；参考：《广东医学》2017年24期

【摘要】：目的检测FOXF1蛋白在胃癌中的表达并探讨其表达差异与临床资料及预后的关系。方法收集160例胃癌患者,利用Oncomine基因芯片数据库预测FOXF1在胃癌中的表达,采用Western blot等方法检测胃癌及其癌旁正常组织中FOXF1蛋白的表达量,将胃癌中FOXF1表达低于癌旁组织的病例设为低表达组,其余病例设为高表达组,分析其与临床资料及病理特征的关系;应用Kaplan-Meier法分析FOXF1蛋白的表达差异与临床预后的相关性。结果 Oncomine数据库及Western blot实验均显示FOXF1蛋白在胃癌中相对表达量明显低于癌旁正常组织(P0.05);FOXF1蛋白低表达与肿瘤的大小、分化及肿瘤分期密切相关(P0.05)。生存分析显示FOXF1蛋白低表达组生存率明显低于高表达组(P0.05)。结论 FOXF1蛋白参与了胃癌的发生和发展,可作为评估胃癌预后的指标。
[Abstract]:Objective to detect the expression of FOXF1 protein in gastric cancer and to explore the relationship between the difference of FOXF1 protein expression and clinical data and prognosis. Methods the expression of FOXF1 in gastric cancer was predicted by Oncomine gene chip database in 160 patients with gastric cancer. The expression of FOXF1 protein in gastric cancer and its adjacent normal tissues was detected by Western blot. The expression of FOXF1 in gastric cancer was lower than that in paracancerous tissues, and the other cases were in high expression group, and the relationship between FOXF1 expression and clinical data and pathological features was analyzed by Kaplan-Meier method, and the correlation between the expression of FOXF1 protein and clinical prognosis was analyzed by Kaplan-Meier method. Results Oncomine database and Western blot assay showed that the relative expression of FOXF1 protein in gastric cancer was significantly lower than that in adjacent normal tissues (P0.05). The low expression of FOXF1 protein was closely related to tumor size, differentiation and tumor stage (P0.05). Survival analysis showed that the survival rate of low expression group of FOXF1 protein was significantly lower than that of high expression group (P0.05). Conclusion FOXF1 protein is involved in the occurrence and development of gastric cancer and can be used as an index to evaluate the prognosis of gastric cancer.
【作者单位】：中山大学附属第三医院胃肠外科;中山大学附属第三医院手术室;
【分类号】：R735.2

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