肺癌癌周灌注的能谱CT初步研究

发布时间：2018-07-04 13:25

  本文选题：肺癌 + 能谱CT成像　； 参考：《重庆医科大学》2017年硕士论文

【摘要】：目的采用能谱CT技术对肺癌癌周灌注进行定量研究,探讨其灌注变化情况及不同分类情况下的灌注差异。方法经病理证实的81例肺癌患者均行能谱CT平扫和增强扫描。在动脉期碘基物质图上分别测量癌周肺组织及健侧镜像区肺组织碘基值,然后计算平均碘浓度(average iodine concentration,ICa),分析比较:所有病例组、中央型及周围型肺癌组癌周与健侧镜像区肺组织的ICa差异;不同部位(中央型、周围型)、肿瘤大小(A组d≤3 cm、B组3d≤7 cm)、病理类型(鳞癌、腺癌、小细胞肺癌)及分化程度(低、低-中、中分化)肺癌组癌周ICa组内差异。结果(1)81例肺癌[(1.26±0.42)mg/ml]、32例中央型[(1.12±0.33)mg/ml]及49例周围型[(1.35±0.45)mg/ml]肺癌癌周肺组织ICa明显低于相应健侧镜像区[(1.65±0.61)mg/ml,(1.63±0.69)mg/ml及(1.66±0.56)mg/ml],差异均具有统计学意义(P0.01)。(2)中央型肺癌癌周肺组织ICa[(1.12±0.33)mg/ml]明显低于周围型[(1.35±0.45)mg/ml](P0.01),10例小细胞肺癌癌周肺组织ICa[(0.94±0.20)mg/ml]低于37例鳞癌[(1.23±0.40)mg/ml]及34例腺癌[(1.37±0.45)mg/ml](P0.05),而后两者之间差异无统计学意义(P0.05)。(3)不同大小肺癌之间以及不同分化程度肺癌之间癌周肺组织ICa差异均无统计学意义(P0.05)。结论肺癌癌周灌注普遍减低,且中央型肺癌低于周围型肺癌,小细胞肺癌低于非小细胞肺癌。肺癌癌周能谱CT灌注特征具有一定理论和临床价值。
[Abstract]:Objective to quantitatively study the pericancerous perfusion of lung cancer by energy dispersive CT (EDS), and to explore the changes of perfusion and the difference of perfusion under different classification. Methods 81 patients with lung cancer proved pathologically underwent plain scan and enhanced scan. The iodine base values of lung tissue around carcinoma and normal mirror region were measured on the arterial phase iodized substance map, and the mean iodine concentration (average iodine concentration) was calculated. The difference of IC a between peripheral and peripheral lung cancer, the size of tumor in different parts (central type, peripheral type), the size of tumor (group A d 鈮，

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