多发性骨髓瘤中c-myc和MDM2蛋白的表达及其临床意义

发布时间：2018-07-04 16:35

本文选题：骨肿瘤 + 多发性骨髓瘤　；参考：《临床与实验病理学杂志》2017年02期

【摘要】：目的探讨c-myc蛋白及小鼠双微体基因(murine double minute 2,MDM2)蛋白在多发性骨髓瘤(multiple myeloma,MM)中的表达及其与临床分期的相关性。方法采用免疫组化SP三步法检测60例不同临床分期MM组织和10例非肿瘤骨髓组织中c-myc蛋白及MDM2蛋白的表达。结果 c-myc蛋白在MM及非肿瘤骨髓组织中的阳性率分别为71.7%、10.0%,MDM2蛋白在MM及非肿瘤骨髓组织中的阳性率分别为80.0%、20.0%,两者在MM及非肿瘤骨髓组织中的表达差异有统计学意义(P0.05)。两者表达与MM的临床分期呈正相关性(P0.05),与MM患者性别、年龄无相关性。MM中c-myc蛋白和MDM2蛋白的表达呈正相关(P0.05)。结论 c-myc蛋白和MDM2蛋白在MM中高表达,其可能与MM的发生及临床分期有关;在MM中,c-myc蛋白和MDM2蛋白可能具有协同作用,共同促进肿瘤的发展。
[Abstract]:Objective to investigate the expression of c-myc protein and mouse double microbody gene (murine double minute 2 / MDM2 protein in multiple myeloma (MM) and their correlation with clinical stages. Methods Immunohistochemical SP three-step method was used to detect the expression of c-myc protein and MDM2 protein in 60 cases of MM with different clinical stages and 10 cases of non-tumor bone marrow tissues. Results the positive rates of c-myc protein in MM and non-tumor bone marrow tissues were 71.7 and 10.0, respectively. The positive rates of MDM2 protein in MM and non-tumor bone marrow tissues were 80.0 and 20.0, respectively. There was significant difference between the two groups in the expression of MDM2 protein in MM and non-tumor bone marrow tissues (P0.05). The expression of c-myc protein and MDM2 protein were positively correlated with the clinical stage of MM (P0.05), but not correlated with the gender of MM patients, age and the expression of MDM2 protein (P0.05). Conclusion c-myc protein and MDM2 protein are highly expressed in MM, which may be related to the occurrence and clinical stage of MM, and c-myc protein and MDM2 protein may have synergistic effect in MM to promote the development of tumor.
【作者单位】：郑州大学第一附属医院病理科;
【基金】：河南省高等学校重点科研项目(17A310036)
【分类号】：R733.3

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