基于荟萃分析的HDL与肺癌相关性的评价

发布时间：2018-07-09 17:09

  本文选题：HDL-C + 肺癌　； 参考：《重庆医科大学》2017年硕士论文

【摘要】：目的:系统评价高密度脂蛋白(HDL)与肺癌的相关性。方法:计算机检索PubMed、ISI Web of Science、EBSCO、The Cochrane Library(2015年8期)、维普期刊资源整合服务平台(VIP)和中国知网(CNKI)数据库,搜集高密度脂蛋白胆固醇(HDL-C)与肺癌相关性的研究,检索时间均限定为建库至2015年9月23日。由两位研究员独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用Stata 12.0软件进行Meta分析。结果:共纳入15个研究,包括1954例患者和15545例对照。Meta分析结果显示,HDL-C水平与肺癌发病相关[SMD=-0.66,95%CI(-0.94,-0.39),P=0.000]。亚组分析结果显示,不同临床分级[SMDI~II=-0.65,95%CI(-1.07,-0.23),P=0.002;SMDⅢ~Ⅳ=-0.61、95%CI(-0.73,-0.50),P=0.000]、不同病理类型(除非小细胞肺癌)[SMD腺癌=-0.76、95%CI(-1.13,-0.38),P=0.000;SMD鳞癌=-1.51、95%CI(-2.47,-0.56),P=0.01;SMD小细胞肺癌=-1.188、95%CI(-1.42,-0.95),P=0.000]、不同研究质量评分[SMD≥6分=-0.60、95%CI(-0.89,-0.29),P=0.000;SMD6分=-0.75、95%CI(-1.37,-0.14),P=0.017]、不同研究例数[SMD≥100例=-0.48、95%CI(-0.80,-0.15),P=0.004;SMD100例=-0.78、95%CI(-1.30,-0.26),P=0.003]、吸烟[SMD=-1.47、95%CI(-2.51,-0.43),P=0.006]以及亚洲地区[SMD=-0.89、95%CI(-1.17,-0.62),P=0.000]肺癌的发病均与HDL-C水平相关。另外,漏斗图基本对称,Begg's检验和Egger's检验显示P值均大于0.05,提示无发表偏倚。结论:HDL水平与肺癌发病相关,低HDL-C水平会增大肺癌的发生风险。鉴于纳入研究的局限性,上述结论尚需进一步开展更多大样本,且调整了吸烟状态的前瞻性队列研究加以验证。
[Abstract]:Objective: to evaluate the correlation between high density lipoprotein (HDL) and lung cancer. Methods: a computer-based search was made for the database of the Cochrane Library (issue 8, 2015), the VIP and CNKI databases, and the correlation between high density lipoprotein cholesterol (HDL-C) and lung cancer. The search time is limited to the construction of the database until September 23, 2015. After two researchers independently sifted the literature, extracted the data and evaluated the bias risk in the study, the Meta-analysis was carried out by Stata 12.0 software. Results: a total of 15 studies were conducted, including 1954 patients and 15545 controls. The results of Meta-analysis showed that HDL-C level was correlated with the incidence of lung cancer [SMD-0.66-95CI (-0.94U -0.39) P 0.000]. Subgroup analysis showed that, 涓嶅悓涓村簥鍒嗙骇[SMDI~II=-0.65,95%CI(-1.07,-0.23),P=0.002;SMD鈪�~鈪，

本文编号：2110049