C-erbB-2、Bmi-1及PTEN基因在大肠癌组织中的表达及意义

发布时间：2018-07-16 20:26

【摘要】：目的研究C-erbB-2、Bmi-1及PTEN基因在大肠癌组织中的表达及其临床意义。方法选取50例大肠癌标本及50例癌旁正常大肠黏膜组织进行免疫组化检测,并分析C-erbB-2、Bmi-1及PTEN基因在两者中的表达及三种基因之间相关性研究。结果(1)C-erbB-2、Bmi-1基因在大肠癌组织中的表达均明显高于在正常大肠组织中的表达,PTEN基因在大肠癌组织中表达显著低于在正常大肠组织中的表达,差异有统计学意义。(2)C-erbB-2、Bmi-1基因与大肠癌的淋巴转移、分化程度、浸润深度、Ducks分期呈正相关,其与大肠癌的发生、发展及生物学行为具有促进作用;而PTEN基因与大肠癌的淋巴转移、分化程度、浸润深度、Ducks分期呈负相关,与大肠癌的发生、发展及生物学行为具有抑制作用。(3)大肠癌组织中C-erbB-2、Bmi-1及PTEN基因之间具有相关性,其中C-erbB-2、Bmi-1基因在大肠癌的发生发展过程中成正相关;C-erbB-2、PTEN基因在大肠癌的发生发展过程中呈负相关;Bmi-1、PTEN基因在大肠癌的发生发展中呈负相关。结论 C-erbB-2、Bmi-1和PTEN基因在大肠癌发生发展中起一定作用,联合检测可能成为预后、靶向治疗的标志物。
[Abstract]:Objective to study the expression of Bmi-1 and PTEN genes in colorectal carcinoma and its clinical significance. Methods Immunohistochemical analysis was performed in 50 colorectal cancer specimens and 50 normal colorectal mucosa adjacent to carcinoma. The expression of C-erbB-2mBmi-1 and PTEN genes and the correlation between the three genes were analyzed. Results (1) the expression of C-erbB-2mBmi-1 gene in colorectal cancer tissues was significantly higher than that in normal colorectal tissues. The expression of PTEN gene in colorectal cancer tissues was significantly lower than that in normal colorectal tissues. The difference was statistically significant. (2) C-erbB-2mBmi-1 gene was positively correlated with lymphatic metastasis, differentiation, depth of invasion and Ducks stage of colorectal cancer, which was positively related to the occurrence, development and biological behavior of colorectal cancer, while PTEN gene was associated with lymphatic metastasis of colorectal carcinoma. The degree of differentiation, depth of invasion and Ducks stage were negatively correlated with the occurrence, development and biological behavior of colorectal cancer. (3) there was a correlation between C-erbB-2mBmi-1 and PTEN gene in colorectal carcinoma. There was a positive correlation between C-erbB-2PTEN gene and Bmi-1 gene in the carcinogenesis and development of colorectal carcinoma. There was a negative correlation between C-erbB-2PTEN gene and Bmi-1 PTEN gene in the carcinogenesis and development of colorectal carcinoma. Conclusion C-erbB-2 Bmi-1 and PTEN genes may play a role in the development of colorectal cancer, and combined detection may be a marker of prognosis and targeted therapy.
【作者单位】：承德医学院;
【分类号】：R735.34

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