内镜下经鼻蝶窦入路行脑垂体瘤切除术后并发颅内感染相关因素分析

发布时间：2018-07-21 12:13

【摘要】：目的探讨分析内镜下经鼻蝶窦入路行脑垂体瘤切除术后并发颅内感染的相关因素,为有效预防和控制感染的发生和发展提供依据。方法选取2012年1月-2014年12月185例在医院行内镜下经鼻碟窦入路脑垂体瘤切除术患者为研究对象,对垂体瘤患者相关资料,术后颅内感染相关危险因素进行统计分析,并对颅内感染患者和非颅内感染患者住院时间和住院费用进行比较分析。结果 185例内镜下经鼻蝶窦入路行脑垂体瘤切除术的患者中,术后发生颅内感染9例,感染率为4.86%;术中出血量120ml、脑脊液漏、糖尿病、术前应用激素、术前应用抗菌药物、术前垂体功能低下以及手术时间4h等因素均能够明显提高颅内感染率,经统计分析,差异均有统计学意义(P0.05);与非颅内感染组患者相比,颅内感染患者住院时间明显延长,住院费用明显提高,经统计分析,差异均有统计学意义(P0.05)。结论内镜下经鼻蝶窦入路行脑垂体瘤切除术并发颅内感染受多种因素的影响,同时影响患者的预后,给患者带来一定的经济负担。
[Abstract]:Objective to investigate the related factors of intracranial infection after endoscopic transsphenoidal resection of pituitary adenoma, and to provide evidence for preventing and controlling the occurrence and development of infection. Methods from January 2012 to December 2014, 185 patients with pituitary adenoma underwent endoscopic transnasal sinus approach were selected as subjects. The data of patients with pituitary adenoma and the risk factors of postoperative intracranial infection were statistically analyzed. The hospitalization time and cost of patients with intracranial infection and non-intracranial infection were compared and analyzed. Results Intracranial infection occurred in 9 of 185 patients undergoing endoscopic transsphenoidal resection of pituitary adenoma, with an infection rate of 4.86.Intraoperative bleeding was 120ml, cerebrospinal fluid leakage, diabetes mellitus was used before operation, and antibiotics were used before operation. The preoperative hypophysis and the operation time of 4 h could significantly increase the intracranial infection rate, the difference was statistically significant (P0.05); compared with the patients with non-intracranial infection, the hospitalization time of the patients with intracranial infection was significantly longer than that of the patients with intracranial infection. The cost of hospitalization increased significantly, the difference was statistically significant (P0.05). Conclusion Endoscopic transsphenoidal approach for pituitary adenoma resection complicated with intracranial infection is affected by many factors and affects the prognosis of the patients and brings a certain economic burden to the patients.
【作者单位】：郑州大学南阳医院南阳市中心医院神经外科二病区;
【基金】：河南省教育厅科学技术研究重点项目(142104510123)
【分类号】：R736.4

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