食管鳞癌组织REGIα表达及临床意义分析
发布时间：2018-07-22 17:10
【摘要】：目的检测食管鳞癌组织中REG Iα的表达情况,分析REG Iα表达情况与临床病理特征及生存间关系,并进一步探讨REG Iα表达状态与辅助化疗的关系。方法回顾性分析2008-1-1至2010-12-31天津医科大学肿瘤医院II/III期单纯手术或者术后接受氟尿嘧啶联合顺铂方案(FP)辅助化疗的食管鳞癌患者(N=135)临床随访资料,采用免疫组织化学S-P方法检测REG Iα的表达情况,采用卡方检验分析REG Iα表达状态与肿瘤原发病灶部位、肿瘤浸润深度(T分期)、TNM分期、淋巴结转移(N分期)、肿瘤组织分化程度(分级)、总生存期等临床病理特征之间的相关性,结合REG Iα的表达情况及随访资料,Kaplan-Meier法和Log-rank检验分析REG Iα与食管癌患者生存的相关性;建立Cox回归模型评估REG Iα及各临床病理因素与患者生存的相关性,并采用Kaplan-Meier法和Log-rank检验进一步探讨REG Iα表达状态与辅助化疗患者生存的关系。结果REG Iα在食管鳞癌组织中表达阳性率为43.70%(59/135),其表达状态与各临床病理特征间相关性无统计学意义。在所有食管鳞癌患者中,REG Iα表达阳性者较其表达阴性者3年生存率低,差异有统计学意义(χ2=6.811,P=0.009)。在单纯手术组中(N=82),REG Iα表达阳性患者3年生存率明显低于REG Iα表达阴性患者(25.00%vs.52.08%,χ2=9.725,P=0.002),且REG Iα表达阳性为单纯手术组患者的一个独立预后因素;而在辅助化疗组(N=53),REG Iα表达阳性患者3年生存率与其表达阴性患者无统计学意义(57.69%vs.52.08%,χ2=0.696,P=0.404)。在所有食管鳞癌患者中,辅助化疗者较单纯手术者3年生存率有提高趋势(58.49 vs.42.68,χ2=2.822,P=0.093),但差异无统计学意义,分层分析显示对于REG Iα表达阳性患者、淋巴结转移阳性患者及吸烟指数≥400患者,接受辅助化疗者较单纯手术者3年生存率明显提高(62.50%vs.27.27%,χ2=5.115,P=0.024;51.43%vs.28.13%,χ2=5.421,P=0.020;60.71%vs.28.57%,χ2=4.737,P=0.030),差异有统计学意义。结论食管鳞癌患者REG Iα表达状态与其生存相关,即REG Iα表达阳性患者生存差;同时也能够提示辅助化疗敏感性,即REG Iα表达阳性患者可能从辅助化疗中获益。
[Abstract]:Objective to detect the expression of REG I 伪 in esophageal squamous cell carcinoma, to analyze the relationship between the expression of REG I 伪 and clinicopathological features and survival, and to explore the relationship between the expression of REG I 伪 and adjuvant chemotherapy. Methods the clinical follow-up data of patients with esophageal squamous cell carcinoma (NQ135) receiving fluorouracil plus cisplatin regimen (FP) were analyzed retrospectively from 2008-1-1 to 2010-12-31, stage II / III surgery or adjuvant chemotherapy of fluorouracil combined with cisplatin (FP) in Tianjin Medical University Oncology Hospital. Immunohistochemical S-P method was used to detect the expression of REG I 伪. The expression of REG I 伪 was analyzed by chi-square test. The expression of REG I 伪 and the location of the primary tumor focus, the depth of tumor invasion (T stage) and TNM stage were analyzed. The correlation between the clinicopathological features of lymph node metastasis (N stage), tumor differentiation degree (grade), total survival time, combined with the expression of REG I 伪, Kaplan-Meier method and Log-rank test were used to analyze the correlation between REG I 伪 and the survival of esophageal cancer patients. Cox regression model was established to evaluate the correlation between the survival of patients with REG I 伪 and the clinicopathological factors. Kaplan-Meier method and Log-rank test were used to further explore the relationship between the expression of REG I 伪 and the survival of patients with adjuvant chemotherapy. Results the positive rate of REGI 伪 expression in esophageal squamous cell carcinoma was 43.70% (59 / 135). In all patients with esophageal squamous cell carcinoma, the 3-year survival rate of patients with positive expression of REG I 伪 was significantly lower than that of patients with negative expression of REGI 伪 (蠂 2 = 6.811 P0. 009). The 3-year survival rate of patients with positive expression of REGI 伪 was significantly lower than that of patients with negative expression of REGI 伪 (25.00 vs.52.08, 蠂 2 9.725 P0. 002), and the positive expression of REGI 伪 was an independent prognostic factor in simple operation group. However, the 3-year survival rate of patients with positive expression of REG I 伪 in the adjuvant chemotherapy group was not significantly different from that of the patients with negative expression (57.69vs.52.08, 蠂 2 = 0.696). In all patients with esophageal squamous cell carcinoma, the 3-year survival rate of adjuvant chemotherapy group was higher than that of simple operation group (58.49 vs.42.68, 蠂 ~ 2 = 2.822, P < 0.093), but the difference was not statistically significant. Stratified analysis showed that REGI 伪 expression was positive in patients. In patients with positive lymph node metastasis and smoking index 鈮，
本文编号：2138172
[Abstract]:Objective to detect the expression of REG I 伪 in esophageal squamous cell carcinoma, to analyze the relationship between the expression of REG I 伪 and clinicopathological features and survival, and to explore the relationship between the expression of REG I 伪 and adjuvant chemotherapy. Methods the clinical follow-up data of patients with esophageal squamous cell carcinoma (NQ135) receiving fluorouracil plus cisplatin regimen (FP) were analyzed retrospectively from 2008-1-1 to 2010-12-31, stage II / III surgery or adjuvant chemotherapy of fluorouracil combined with cisplatin (FP) in Tianjin Medical University Oncology Hospital. Immunohistochemical S-P method was used to detect the expression of REG I 伪. The expression of REG I 伪 was analyzed by chi-square test. The expression of REG I 伪 and the location of the primary tumor focus, the depth of tumor invasion (T stage) and TNM stage were analyzed. The correlation between the clinicopathological features of lymph node metastasis (N stage), tumor differentiation degree (grade), total survival time, combined with the expression of REG I 伪, Kaplan-Meier method and Log-rank test were used to analyze the correlation between REG I 伪 and the survival of esophageal cancer patients. Cox regression model was established to evaluate the correlation between the survival of patients with REG I 伪 and the clinicopathological factors. Kaplan-Meier method and Log-rank test were used to further explore the relationship between the expression of REG I 伪 and the survival of patients with adjuvant chemotherapy. Results the positive rate of REGI 伪 expression in esophageal squamous cell carcinoma was 43.70% (59 / 135). In all patients with esophageal squamous cell carcinoma, the 3-year survival rate of patients with positive expression of REG I 伪 was significantly lower than that of patients with negative expression of REGI 伪 (蠂 2 = 6.811 P0. 009). The 3-year survival rate of patients with positive expression of REGI 伪 was significantly lower than that of patients with negative expression of REGI 伪 (25.00 vs.52.08, 蠂 2 9.725 P0. 002), and the positive expression of REGI 伪 was an independent prognostic factor in simple operation group. However, the 3-year survival rate of patients with positive expression of REG I 伪 in the adjuvant chemotherapy group was not significantly different from that of the patients with negative expression (57.69vs.52.08, 蠂 2 = 0.696). In all patients with esophageal squamous cell carcinoma, the 3-year survival rate of adjuvant chemotherapy group was higher than that of simple operation group (58.49 vs.42.68, 蠂 ~ 2 = 2.822, P < 0.093), but the difference was not statistically significant. Stratified analysis showed that REGI 伪 expression was positive in patients. In patients with positive lymph node metastasis and smoking index 鈮，
本文编号：2138172
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