AR及BMP-2在浸润性乳腺癌组织中的表达及临床病理意义
发布时间：2018-07-29 20:37
【摘要】：目的:探讨浸润性乳腺癌患者原发灶中骨形成蛋白(bone morphogenetic protein-2,BMP-2)及雄激素受体(androgen receptor,AR)的表达情况,并探讨其与临床病理特征的关系。方法:收集新疆医科大学附属肿瘤医院2009年1月至2014年12月经手术切除并经病理诊断的浸润性乳腺癌123例,采用免疫组织化学方法检测AR,BMP-2在浸润性乳腺癌患者原发灶中的表达情况,并分析其与临床病理特征的相关性。结果:本研究所选123例浸润性乳腺癌病例中,BMP-2阳性共计114例(92.7%),AR阳性共计98例(79.7%);在肿瘤大小分组中,肿瘤5cm病例中AR阳性率100%,2-5cm病例中AR阳性率90.7%,"f2cm病例中AR阳性率71.6%,三组表达有统计学差异(=35.168,P0.01);在不同组织学分级分组中,Ⅰ级AR阳性率80%,Ⅱ级AR阳性率88.9%,Ⅲ级AR阳性率59.5%,三组表达差异有统计学意义(=14.494,P=0.025);Ⅰ级BMP-2阳性率80%,Ⅱ级BMP-2阳性率97.5%,Ⅲ级BMP-2阳性率83.3%,表达差异有统计学意义(=13.853,P=0.031);ER阳性组AR阳性率87.4%,ER阴性的AR阳性率53.6%,两组表达差异有统计学意义(=16.868,P=0.001);PR阳性组AR表达率87.5%,PR阴性组AR表达率60%,两组表达差异有统计学意义(=12.822,P=0.005);AR阳性组BMP-2阳性率95.9%,AR阴性组BMP-2阳性率80%,两组表达差异有统计学意义(=8.909,P=0.031);在分子分型中的阳性率分别为,Luminal A型(80.0%)、Luminal B型(87.4%)、Her-2过表达型(52.6%)、Basal-like型(0),差异有统计学意义(=23.456,P=0.005)。本研究中发生骨转移病例85例,未发生骨转移病例38例,有腋窝淋巴结转移组AR阳性率88.4%,无腋窝淋巴结转移组68.5%,两组之间AR表达差异有统计学意义(=8.615,P=0.035);有神经脉管侵犯组的AR阳性表达率为96.3%,无神经脉管侵犯组阳性表达率75.0%,两组之间AR表达差异有统计学意义(=34.143,P0.01);而在年龄,临床分期,骨转移、Her-2阳性、阴性组,Ki-67阳性、阴性组中的AR表达差异无统计学意义(P0.05);在年龄、临床分期、肿瘤大小、神经脉管侵犯、淋巴结转移、骨转移及ER,PR,Her-2,Ki-67等分组中BMP-2表达差异无统计学意义(P0.05)。结论:在组织学分级中,Ⅱ级BMP-2阳性率、AR阳性率高于Ⅰ级、三级;在肿瘤大小分组中,AR阳性率随着肿瘤直径的增大而增高。在分子分型中,AR阳性率由高到低分别为Luminal B型、Luminal A型、Her-2过表达型、Basal-like型,BMP-2表达率由高到低分别为Basal-like型、Luminal B、Luminal A型、Her-2过表达型。在淋巴结转移组中,AR阳性率在有腋窝淋巴结转移组高于无腋窝淋巴结转移组;在神经脉管侵犯组中,AR阳性表达率在有神经脉管侵犯组高于无神经脉管侵犯组。AR阳性组BMP-2阳性率高于AR阴性组BMP-2阳性率,而且AR高表达的组织中BMP-2也呈高表达,AR低表达的组织中BMP-2也呈低表达。AR与ER、PR在乳腺癌组织中的表达具有一定的相关性,并在乳腺癌的浸润及转移过程中发挥重要作用;BMP-2无法独立为浸润性乳腺癌患者骨转移提供风险预警。
[Abstract]:Objective: to investigate the expression of bone morphogenetic protein (bone morphogenetic protein-2BMP-2 (BMP-2) and androgen receptor AR (androgen receptor AR) in primary lesions of invasive breast cancer and their relationship with clinicopathological features. Methods: 123 cases of invasive breast cancer diagnosed by pathology from January 2009 to December 2014 in Cancer Hospital affiliated to Xinjiang Medical University were collected. Immunohistochemical method was used to detect the expression of ARN BMP-2 in primary lesions of invasive breast cancer and its correlation with clinicopathological features was analyzed. Results: in 123 cases of invasive breast cancer, 114 cases (92.7%) were positive for BMP-2 and 98 cases (79.7%) were positive for AR. The positive rate of AR in tumor 5cm cases was 90.7 in 2 ~ 5cm cases, "the positive rate of AR in f2cm cases was 71.6, there was statistical difference among the three groups (P 0.01), and in different histological grading groups, there was a significant difference in AR positive rate among the three groups (P < 0.05). The positive rate of AR was 80 in grade 鈪，
本文编号：2153944
[Abstract]:Objective: to investigate the expression of bone morphogenetic protein (bone morphogenetic protein-2BMP-2 (BMP-2) and androgen receptor AR (androgen receptor AR) in primary lesions of invasive breast cancer and their relationship with clinicopathological features. Methods: 123 cases of invasive breast cancer diagnosed by pathology from January 2009 to December 2014 in Cancer Hospital affiliated to Xinjiang Medical University were collected. Immunohistochemical method was used to detect the expression of ARN BMP-2 in primary lesions of invasive breast cancer and its correlation with clinicopathological features was analyzed. Results: in 123 cases of invasive breast cancer, 114 cases (92.7%) were positive for BMP-2 and 98 cases (79.7%) were positive for AR. The positive rate of AR in tumor 5cm cases was 90.7 in 2 ~ 5cm cases, "the positive rate of AR in f2cm cases was 71.6, there was statistical difference among the three groups (P 0.01), and in different histological grading groups, there was a significant difference in AR positive rate among the three groups (P < 0.05). The positive rate of AR was 80 in grade 鈪，
本文编号：2153944
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