NK细胞的免疫监视作用及肿瘤免疫逃逸

发布时间：2018-08-03 17:41

【摘要】：自然杀伤(NK)细胞在机体抗肿瘤及抗感染免疫中发挥着重要的免疫监视作用,在杀伤肿瘤细胞的过程中,不需要肿瘤特异性抗原的识别便可以直接发挥杀伤效应,故NK细胞对肿瘤细胞的杀伤作用更直接、更迅速,在肿瘤免疫治疗方面具有显著优势。NK细胞的免疫监视功能主要与其表面不同类型受体的表达有关,如NKG2D、自然杀伤细胞毒性受体(NCR)、CD226等。而肿瘤细胞则可以利用肿瘤微环境中多种因素逃逸NK细胞的免疫监视,如血小板、腺苷酸、细胞因子、吲哚胺2,3双加氧酶(IDO)等,进而形成肿瘤并发生转移。因此肿瘤微环境中诱导肿瘤逃逸NK细胞免疫监视的这些因素,有可能成为今后提高NK细胞免疫治疗疗效的候选靶点之一。
[Abstract]:Natural killer (NK) cells play an important role in anti-tumor and anti-infection immunity. In the process of killing tumor cells, tumor specific antigen recognition is not needed to directly play a killing effect. Therefore, NK cells have a more direct and rapid killing effect on tumor cells. The immune surveillance function of NK cells is mainly related to the expression of different types of receptors on the surface of tumor immunotherapy. For example, NKG 2 D, natural killer cytotoxic receptor (NCR) CD 226, and so on. However, tumor cells can use many factors in tumor microenvironment to escape the immune surveillance of NK cells, such as platelets, adenylate, cytokines, indoleamine 2Ox 3-dioxygenase (IDO), and then form tumors and metastasize. Therefore, these factors that induce tumor escape in tumor microenvironment may be one of the candidate targets to improve the efficacy of NK cell immunotherapy in the future.
【作者单位】：上海中医药大学免疫学与病原生物学教研室;上海中医药大学科技实验中心;
【基金】：上海市卫生和计划生育委员会科研课题(20154Y0167)
【分类号】：R730.51

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